Document Detail

Plasmatic level of leukocyte-derived microparticles is associated with unstable plaque in asymptomatic patients with high-grade carotid stenosis.
MedLine Citation:
PMID:  23707318     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To analyze whether plasmatic level of leukocyte-derived microparticles (LMP) is associated with unstable plaques in patients with high-grade carotid stenosis. BACKGROUND: Preventive carotid surgery in asymptomatic patients is currently debated given the improvement of medical therapy. Therefore, non-invasive biomarkers that can predict plaque instability are needed. LMP, originating from activated or apoptotic leukocytes are the major microparticle subset in human carotid plaque extracts. METHODS: Forty-two patients with greater than 70% carotid stenosis were enrolled. Using a new standardized high-sensitivity flow cytometry assay, LMPs were measured before thromboendarterectomy. The removed plaques were characterized as stable or unstable using histological analysis according to the AHA criteria. LMP levels were analyzed according to the plaque morphology. RESULTS: The median LMP levels were significantly higher in patients with unstable plaque (n= 28, CD11bCD66b+MP/μl: 240 [147-394] [25th percentile - 75th percentile], and CD15+MP/μl: 147 [60-335]) compared to those with stable plaque (16 [0-234] and 55 [36-157], p<0.001 and p<0.01, respectively). The increase in LMP levels was also significant when considering only the group of asymptomatic patients with unstable plaque (n=10; CD11bCD66b+MP/μl: 199 [153-410] and CD15+MP/μl: 78 [56-258] compared to those with stable plaque (n=14, 20 [0-251] and 55 [34-102], p<0.05 and p<0.05, respectively). After logistic regression, the neurologic symptoms (OR 48.7, 95% CI 3.0-788, p<0.01) and the level of CD11bCD66b+MPs (OR 24.4, 95% CI 2.4-245, p<0.01) independently predicted plaque instability. CONCLUSIONS: LMP constitute a promising biomarker associated with plaque vulnerability in patients with high-grade carotid stenosis. These data provide clues for identifying asymptomatic subjects that are most at risk of neurologic events.
G Sarlon-Bartoli; Y Bennis; R Lacroix; Piercecchi -Marti; M D Bartoli; L Arnaud; J Mancini; A Boudes; E Sarlon; B Thevenin; A S Leroyer; C Squarcioni; P E Magnan; F Dignat-George; F Sabatier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-22
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  -     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Service de Chirurgie Vasculaire, Faculté de Médecine de Marseille, Aix-Marseille Université, Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone, Marseille, France; INSERM UMR-1076, Faculté de Pharmacie, Aix-Marseille Université, Marseille, France.
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