Document Detail

Plasmapheresis for severe, unremitting, chronic urticaria.
MedLine Citation:
PMID:  1373787     Owner:  NLM     Status:  MEDLINE    
Histamine-releasing autoantibodies have been identified in chronic idiopathic urticaria. 8 patients with severe disease and histamine-releasing activity in their sera underwent plasmapheresis. Symptoms were abolished for 2 months in 1 patient and for 3 weeks in another, 2 showed almost complete resolution of symptoms, 2 had temporary relief, and the other 2 showed little change. Further investigation in 4 of the patients showed significantly reduced skin-test responses to fresh post-exchange autologous sera after plasmapheresis compared with stored pre-exchange sera, but the response to intradermal histamine remained unchanged. Blood cellular histamine increased as in-vitro serum histamine-releasing activity fell after plasmapheresis. These results favour a pathogenetic role for histamine-releasing autoantibodies in patients with chronic urticaria.
C E Grattan; D M Francis; N G Slater; R J Barlow; M W Greaves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  339     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-28     Completed Date:  1992-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1078-80     Citation Subset:  AIM; IM    
St John's Institute of Dermatology, UMDS, London, UK.
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MeSH Terms
Autoantibodies / metabolism
Histamine / blood
Histamine Release
Middle Aged
Urticaria / metabolism,  therapy*
Reg. No./Substance:
0/Autoantibodies; 51-45-6/Histamine

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