Document Detail


Plasmapheresis and pregnancy outcome in patients with antiphospholipid syndrome.
MedLine Citation:
PMID:  17897649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess plasmapheresis with low dose prednisone on obstetric and neonatal outcomes among unsuccessfully treated pregnant women with documented antiphospholipid syndrome (APS). METHODS: Eighteen pregnant women received prednisone (10 mg/day) and plasmapheresis at 7.08+/-0.6 weeks of gestation, for 3 sessions per week, until lupus anticoagulant activity suppressed and IgG anticardiolipin lowered. Serial pulsatility indexes (PI) of umbilical and uterine arteries were performed. RESULTS: The live birth rate was 100%; mild pre-eclampsia 5.5%; preterm deliveries 22.22%; intrauterine growth restriction 11.11%; thrombocytopenia 5.5%; oligohydramnios and fetal distress 16.6%. There were no perinatal deaths, thrombotic events or lupus flare. Uterine artery PI was reduced and umbilical artery PI was >95th percentile. CONCLUSION: Plasmapheresis and low dose prednisone were associated with a low rate of obstetric and neonatal complications. Plasmapheresis may be used to treat pregnant women with documented APS when first lines (aspirin and/or heparin) fail to prevent pregnancy loss.
Authors:
D O El-Haieg; M F Zanati; F M El-Foual
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-09-25
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  99     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Affiliation:
Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt. drdalia65@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / therapy*
Adult
Anti-Inflammatory Agents / therapeutic use
Antiphospholipid Syndrome / therapy*
Female
Humans
Live Birth
Pilot Projects
Plasmapheresis*
Prednisone / therapeutic use
Pregnancy
Pregnancy Complications, Hematologic / therapy*
Pulsatile Flow
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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