Document Detail

Plasmacytoid monocytes in Jessner's lymphocytic infiltration of the skin. A valuable clue for the diagnosis.
MedLine Citation:
PMID:  1928616     Owner:  NLM     Status:  MEDLINE    
Plasmacytoid monocytes (PCMs) are mononuclear cells of monocyte/macrophage origin with peculiar plasmacytoid features on electron microscopy. This cell type is largely unknown in dermatopathology, probably due to standard fixation procedures. The authors provide a detailed histopathologic, immunohistochemical, and electron-microscopic study of PCMs in Jessner's lymphocytic infiltration of the skin (LIS). PCMs occurred in 58% of all biopsy specimens from 75 patients with LIS in single or multiple clusters within the dermal infiltrates. Recognition of this cell type was important for differential diagnostic reasons because PCMs did not occur in polymorphic light eruption. In discoid lupus erythematosus, PCMs were present in only 7.3% of 110 biopsy specimens. PCMs are probably involved in the activation, proliferation, and differentiation of T-lymphocytes. Their origin and function are discussed and a special role in the homing of lymphocytes into the skin is suggested.
J Toonstra; S C van der Putte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  13     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-30     Completed Date:  1991-10-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  IM    
Department of Dermatology, Utrecht University Hospital, The Netherlands.
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MeSH Terms
Diagnosis, Differential
Lupus Erythematosus, Discoid / pathology
Lymphocytes / pathology*
Monocytes / immunology,  pathology*
Photosensitivity Disorders / pathology
Skin / pathology*
Skin Diseases / diagnosis,  immunology,  pathology*

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