| Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. | |
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MedLine Citation:
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PMID: 18641647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection. This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes. Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them. However, in some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signalling. Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis. |
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Authors:
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Michel Gilliet; Wei Cao; Yong-Jun Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 8 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-25 Completed Date: 2008-08-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 594-606 Citation Subset: IM |
Affiliation:
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Department of Immunology and Center of Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Vesicular Transport
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immunology Autoimmune Diseases / immunology* Dendritic Cells / immunology* Humans Immunity, Innate Interferon Type I / immunology Myeloid Differentiation Factor 88 / immunology Nucleic Acids / immunology* Signal Transduction Toll-Like Receptors / immunology Virus Diseases / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Vesicular Transport; 0/Interferon Type I; 0/MYD88 protein, human; 0/Myeloid Differentiation Factor 88; 0/Nucleic Acids; 0/TICAM1 protein, human; 0/Toll-Like Receptors |
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