| Plasmacytoid dendritic cells in the skin: to sense or not to sense nucleic acids. | |
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MedLine Citation:
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PMID: 19250840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasmacytoid dendritic cells (pDCs) are specialized sensors of viral nucleic acids that initiate protective immunity through the production of type I interferons (IFNs). Normally, pDCs fail to sense host-derived self-nucleic acids but do so when self-nucleic acids form complexes with endogenous antimicrobial peptides produced in damaged skin. Whereas regulated expression of antimicrobial peptides may lead to pDC activation and protective immune responses to skin injury, overexpression of antimicrobial peptides in psoriasis drives excessive sensing of self-nucleic acids by pDCs resulting in IFN-driven autoimmunity. In skin tumors, pDCs are unable to sense self-nucleic acids; however, therapeutic activation of pDCs by synthetic nucleic acids or analogues can be exploited to generate antitumor immunity. |
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Authors:
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Curdin Conrad; Stephan Meller; Michel Gilliet |
Publication Detail:
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Type: Journal Article; Review Date: 2009-02-27 |
Journal Detail:
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Title: Seminars in immunology Volume: 21 ISSN: 1096-3618 ISO Abbreviation: Semin. Immunol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 101-9 Citation Subset: IM |
Affiliation:
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Department of Immunology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Differentiation / metabolism* Autoimmunity Cell Communication Cell Differentiation Cell Movement Dendritic Cells / immunology*, metabolism Humans Immunity, Innate* Infection / immunology, pathology Interferon Type I / secretion* Neoplasms / immunology, pathology Nucleic Acids / immunology*, metabolism Skin / immunology, pathology Toll-Like Receptors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Differentiation; 0/Interferon Type I; 0/Nucleic Acids; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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