Document Detail


Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins.
MedLine Citation:
PMID:  23422476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may contribute to the induction of neuroinflammation. Therefore, reports of human endogenous retroviral (HERV) expression in association with neuroinflammatory diseases prompted us to investigate the gut of individuals with ME for the presence of HERV proteins. In eight out of 12 individuals with ME, immunoreactivity to HERV proteins was observed in duodenal biopsies. In contrast, no immunoreactivity was detected in any of the eight controls. Immunoreactivity to HERV Gag and Env proteins was uniquely co-localized in hematopoietic cells expressing the C-type lectin receptor CLEC4C (CD303/BDCA2), the co-stimulatory marker CD86 and the class II major histocompatibility complex HLA-DR, consistent with plasmacytoid dendritic cells (pDCs). Although the significance of HERVs present in the pDCs of individuals with ME has yet to be determined, these data raise the possibility of an involvment of pDCs and HERVs in ME pathology. To our knowledge, this report describes the first direct association between pDCs and HERVs in human disease.
Authors:
Kenny L De Meirleir; Svetlana F Khaiboullina; Marc Frémont; Jan Hulstaert; Albert A Rizvanov; András Palotás; Vincent C Lombardi
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-22     Revised Date:  2013-09-20    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  177-87     Citation Subset:  IM    
Affiliation:
Whittemore Peterson Institute for Neuro-Immune Disease, University of Nevada, Reno 1664 N Virginia Street MS 0552, Reno, NV 89557 USA.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / blood*,  immunology
Dendritic Cells / immunology*,  pathology
Duodenum / immunology*,  pathology
Fatigue Syndrome, Chronic / immunology*,  pathology
Fluorescent Antibody Technique, Indirect
Humans
Plasma Cells / immunology*,  pathology
Retroviridae Proteins / immunology*
Grant Support
ID/Acronym/Agency:
AI078234/AI/NIAID NIH HHS; R01 AI078234/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Retroviridae Proteins
Comments/Corrections

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