Document Detail

Plasmacellular and granulomatous splenomegaly produced in rats by tin.
MedLine Citation:
PMID:  6605879     Owner:  NLM     Status:  MEDLINE    
Two intravenous inoculations of metallic tin powder caused a striking, self-limited enlargement of the spleen up to five or six times its normal size. In addition to epithelioid cell granulomas in response to the foreign particles, the spleen contained extensive accumulations of plasmablasts, plasma cells, and plasma cells containing Russell bodies. The proliferative activity of the immature plasma cells was indicated by the high incidence of mitoses and cells labeled with tritiated thymidine. In contrast, the granulomas had no mitoses or labeling. A single intravenous injection of tin usually produced little or no reaction in the spleen despite an abundance of tin particles. Two intravenous injections or one intravenous and one intraperitoneal inoculation were much more effective. Experiments on route, interval, and dose suggested that the first dose of tin prepared the spleen in some manner while the second dose actually elicited the reaction. Pertussis vaccine or glucan could substitute for one of the tin injections. This new model is of interest for the study of plasma cell hyperplasia and also for revealing the pathogenic potential of metallic tin.
S Levine; R Sowinski; S Koulish
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and molecular pathology     Volume:  39     ISSN:  0014-4800     ISO Abbreviation:  Exp. Mol. Pathol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370711     Medline TA:  Exp Mol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-76     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Granuloma / chemically induced,  pathology*
Hyperplasia / chemically induced,  pathology
Organ Size / drug effects
Plasma Cells / pathology*
Rats, Inbred Lew
Spleen / anatomy & histology,  pathology
Splenomegaly / chemically induced,  pathology
Tin / administration & dosage,  toxicity*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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