Document Detail

Plasmablasts and plasma cells: reconsidering teleost immune system organization.
MedLine Citation:
PMID:  21477614     Owner:  NLM     Status:  MEDLINE    
Comparative immunologists have expended extensive efforts in the characterization of early fish B cell development; however, analysis of the post-antigen induction stages of antibody secreting cell (ASC) differentiation has been limited. In contrast, work with murine ASCs has resolved the physically and functionally distinct cells known as plasmablasts, the short-lived plasma cells and long-lived plasma cells. Teleost ASCs are now known to also possess comparable subpopulations, which can greatly differ in such basic functions as lifespan, antigen sensitivity, antibody secretion rate, differentiative potential, and distribution within the body. Understanding the mechanisms by which these subpopulations are produced and distributed is essential for both basic understanding in comparative immunology and practical vaccine engineering.
Jianmin Ye; Ilsa Kaattari; Stephen Kaattari
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-04-06
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  35     ISSN:  1879-0089     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-04-10     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1273-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage
Antibody Formation
Antibody-Producing Cells / cytology,  immunology*
Bacteria / immunology
Bacterial Infections / immunology*,  microbiology,  prevention & control
Cell Differentiation / immunology
Fishes / genetics*,  immunology
Hemocyanin / administration & dosage
Immunity, Innate*
Kidney / cytology,  immunology
Lipopolysaccharides / administration & dosage
Plasma Cells* / cytology,  immunology
Vaccines / administration & dosage,  immunology
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Lipopolysaccharides; 0/Vaccines; 9013-72-3/Hemocyanin; FV4Y0JO2CX/keyhole-limpet hemocyanin

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