Document Detail

Plasmablastic lymphoma of the oral cavity: a review.
MedLine Citation:
PMID:  20138565     Owner:  NLM     Status:  MEDLINE    
Plasmablastic lymphoma (PBL) is a rare AIDS associated non-Hodgkin's lymphoma (NHL), with predilection for the mucosa of oral cavity. It usually has a plasmablastic morphology, expressing plasma cell-associated antigens with weak or no expression of B-cell associated markers. The tumor cells also show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of Ig light chain (IgL) gene expression in most of the cases. An etiological role for EBV seems likely but the association with HHV8 is questionable. The treatment guidelines for PBL are not well defined and patients have been treated heterogeneously with chemo and/or radiotherapy, although the prognosis is poor. The present article discusses the 68 cases reported in English medical literature with comprehensive review on PBL involving the oral cavity.
Sachin C Sarode; Gargi S Sarode; Anuprita Patil
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-06
Journal Detail:
Title:  Oral oncology     Volume:  46     ISSN:  1879-0593     ISO Abbreviation:  Oral Oncol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2011-03-31     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  146-53     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Gene Rearrangement, B-Lymphocyte / genetics
Lymphoma, AIDS-Related / immunology,  pathology*,  therapy
Mouth Neoplasms / immunology,  pathology*,  therapy

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