Document Detail


Plasmablastic lymphoma involving the penis: a previously unreported location of a case with aberrant CD3 expression.
MedLine Citation:
PMID:  21240066     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Lymphomas of the penis are rare and can either arise at this site or be a manifestation of systemic disease. We report the case of an elderly man with a plasmablastic lymphoma (PBL) involving the uncircumcised penile prepuce. The neoplasm was composed of plasmablasts positive for monotypic immunoglobulin lambda light chain, CD3, CD79a, CD138 and Epstein-Barr virus encoded RNA (EBER), and was negative for CD2, CD5, CD7, CD20, and PAX5. This case is highly unusual for at least two reasons. The penile foreskin is a rare location for lymphoma and PBL at this site has not been reported. Secondly, the tumour was shown by immunohistochemistry to be positive for the T-cell marker CD3. Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed.
Authors:
Jianlan Sun; L Jeffrey Medeiros; Pei Lin; Gary Lu; Carlos E Bueso-Ramos; M James You
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology     Volume:  43     ISSN:  1465-3931     ISO Abbreviation:  Pathology     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
Affiliation:
The Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
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