| Plasmablastic lymphoma involving the penis: a previously unreported location of a case with aberrant CD3 expression. | |
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MedLine Citation:
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PMID: 21240066 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lymphomas of the penis are rare and can either arise at this site or be a manifestation of systemic disease. We report the case of an elderly man with a plasmablastic lymphoma (PBL) involving the uncircumcised penile prepuce. The neoplasm was composed of plasmablasts positive for monotypic immunoglobulin lambda light chain, CD3, CD79a, CD138 and Epstein-Barr virus encoded RNA (EBER), and was negative for CD2, CD5, CD7, CD20, and PAX5. This case is highly unusual for at least two reasons. The penile foreskin is a rare location for lymphoma and PBL at this site has not been reported. Secondly, the tumour was shown by immunohistochemistry to be positive for the T-cell marker CD3. Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed. |
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Authors:
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Jianlan Sun; L Jeffrey Medeiros; Pei Lin; Gary Lu; Carlos E Bueso-Ramos; M James You |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pathology Volume: 43 ISSN: 1465-3931 ISO Abbreviation: Pathology Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0175411 Medline TA: Pathology Country: England |
Other Details:
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Languages: eng Pagination: 54-7 Citation Subset: IM |
Affiliation:
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The Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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