Document Detail


Plasmablastic lymphoma: a clinicopathologic correlation.
MedLine Citation:
PMID:  16414538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmablastic lymphoma (PBL) is an uncommon, recently described B-cell-derived lymphoma that displays distinctive affinity for extranodal presentation in the oral cavity. Plasmablastic lymphoma is strongly associated with human immunodeficiency virus (HIV) infection, but has been reported in HIV-negative individuals. Plasmablastic lymphoma may be poorly recognized by pathologists, which is partly attributable to its relatively rare occurrence and unusual immunophenotype. Five cases of oral cavity lymphomas conforming to the current World Health Organization morphological criteria for PBL were retrieved from the consultation files at the Armed Forces Institute of Pathology. An immunohistochemical panel consisting of CD3, CD20, CD30, CD38, CD45RB, CD79a, CD138, Bcl-2, Bcl-6, Alk-1, Ki-67, EBV-LMP-1, and HHV8 was performed. All 5 cases were immunoreactive for CD38 and/or CD138, confirming plasma cell differentiation of the tumor cells. CD20 was immunoreactive in 1 case, and CD79a was positive in 2 cases. HHV8 and EBV-LMP-1 were nonreactive in all cases. Follow-up revealed only 1 patient alive with no evidence of disease. Our cases show that PBL is an aggressive type of B-cell lymphoma predominantly found in the oral cavity. Plasmablastic lymphoma is often associated with HIV infection.
Authors:
Gretchen S Folk; Susan L Abbondanzo; Esther L Childers; Robert D Foss
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  10     ISSN:  1092-9134     ISO Abbreviation:  Ann Diagn Pathol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-12     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. gsfolk@nmcsd.med.navy.mil
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD38 / metabolism
Female
Humans
Immunohistochemistry
Lymphoma, AIDS-Related / pathology*,  virology
Lymphoma, B-Cell / pathology*,  virology
Male
Membrane Glycoproteins / metabolism
Middle Aged
Mouth / pathology*
Mouth Neoplasms / pathology*,  virology
Plasma Cells / pathology*,  virology
Proteoglycans / metabolism
Syndecan-1
Syndecans
Tumor Markers, Biological / metabolism
Chemical
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Proteoglycans; 0/SDC1 protein, human; 0/Syndecan-1; 0/Syndecans; 0/Tumor Markers, Biological; EC 3.2.2.5/Antigens, CD38

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