Document Detail

Plasma and white adipose tissue lipid composition in marmots.
MedLine Citation:
PMID:  2337195     Owner:  NLM     Status:  MEDLINE    
White adipose tissue biopsies and plasma samples were obtained from hibernating yellow-bellied marmots (Marmota flaviventris) maintained in the laboratory. In addition, biopsies and plasma samples were obtained from normothermic animals in the field and laboratory. Measurement of plasma free fatty acid (FA) levels indicated that winter laboratory animals exhibited increased lipolysis. Additionally, analysis of white adipose tissue triacylglycerol revealed that the FA composition of the storage fat in animals maintained on the standard laboratory diet is remarkably simple and uniform between different adipose depots in the same animal. Three FAs (palmitic, oleic, and linoleic acids) made up greater than 95% of the total. Triene (alpha-linolenate) was found in newly captured animals, but the percentage of this FA decreased rapidly when the animals were maintained on the standard laboratory diet. Throughout the hibernation season (October to April), white adipose tissue-saturated FA percentage decreased, monoene percentage remained constant, and diene percentage increased. Analysis of plasma FA composition suggested that these animals tended to metabolize saturated FAs from stored lipid during hibernation and that dienes were mobilized briefly after the last arousal from hibernation in spring. From these observations, we hypothesize that marmots preferentially metabolize saturated fats during the hibernation period and that essential FAs of the omega 6 series tend to be metabolized more slowly than other FAs. These characteristics suggest that marmots are a valuable animal model in which to study lipid metabolism.
G L Florant; L C Nuttle; D E Mullinex; D A Rintoul
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1123-31     Citation Subset:  IM; S    
Department of Biology, Swarthmore College, Pennsylvania 19081.
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MeSH Terms
Adipose Tissue / metabolism*
Animals, Laboratory / blood,  metabolism
Animals, Wild / blood,  metabolism
Body Weight
Fatty Acids / blood
Lipid Metabolism*
Lipids / blood
Marmota / anatomy & histology,  blood,  metabolism*
Sciuridae / metabolism*
Triglycerides / classification,  metabolism
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Triglycerides

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