Document Detail

Plasma volume shifts during moderate exercise in splenectomized greyhounds.
MedLine Citation:
PMID:  490369     Owner:  NLM     Status:  MEDLINE    
1. Plasma volume was measured in splenectomized greyhounds, using T-1824, and sequential changes in plasma volume were measured using two independent methods, based on T-1824 plasma decay characteristics and on changes in haematocrit. 2. There were no significant differences between estimates of plasma volume made by the two methods in resting or exercising dogs. Therefore it was concluded that the characteristics of the decay of dye concentration in plasma were not affected by exercise and that sequential determinations of plasma volume from a single dye injection provide a valid determination of plasma volume during exercise in dogs. 3. During submaximal exercise, the plasma volume increased by 0-11.8% of its initial value. In no case did plasma volume decrease significantly. 4. An increase in plasma volume during excercise was also seen in animals previously made acutely hypervolemic or hypovolemic. 5. It is suggested that the increase in plasma volume constitutes part of a mechanism maintaining oxygen delivery to tissues during exercise.
I H Sarelius
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  292     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-12-18     Completed Date:  1979-12-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  391-405     Citation Subset:  IM    
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MeSH Terms
Blood Volume
Erythrocyte Volume
Evans Blue
Physical Exertion*
Plasma Volume*
Reg. No./Substance:
314-13-6/Evans Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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