Document Detail

Plasma volume regulation: defences against edema formation (with special emphasis on hypoproteinemia).
MedLine Citation:
PMID:  8116692     Owner:  NLM     Status:  MEDLINE    
In hypoproteinemia, increased interstitial hydrostatic and decreased interstitial colloid osmotic pressures, together with increases in lymph flow, prevent interstitial fluid volume expansion, thus forming the edema-preventing mechanisms. Transfer of a substantial portion of the interstitial protein pool into the vascular compartment by increased lymph flow is the major edema-preventing mechanism. The increase in interstitial pressure during progressive interstitial fluid volume expansion is limited by the high compliance of the interstitium in most tissues. During hypoproteinemia low interstitial colloid osmotic pressure and high interstitial compliance permit augmented changes in plasma volume in response to rapid increases (orthostasis, venous constriction) and decreases (hemorrhage) in capillary pressure. Nevertheless, these same forces are responsible for the finding that during the relatively slow changes in sodium balance that occur during volume retention or after treatment with diuretics, the change in plasma volume is relatively small. These phenomena are illustrated by observations gathered in experimental hypoproteinemia and in patients with the nephrotic syndrome.
J A Joles; T J Rabelink; B Braam; H A Koomans
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  American journal of nephrology     Volume:  13     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-31     Completed Date:  1994-03-31     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  399-412     Citation Subset:  IM    
Department of Nephrology and Hypertension, University Hospital, Utrecht, The Netherlands.
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MeSH Terms
Edema / etiology,  physiopathology*
Extracellular Space / physiology
Hypoproteinemia / complications,  physiopathology*
Lymph / physiology
Nephrotic Syndrome / physiopathology
Plasma Volume / physiology*

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