Document Detail

Plasma volume changes during and after acute variations of body hydration level in humans.
MedLine Citation:
PMID:  10367716     Owner:  NLM     Status:  MEDLINE    
This study examined plasma volume changes (deltaPV) in humans during periods with or without changes in body hydration: exercise-induced dehydration, heat-induced dehydration and glycerol hyperhydration. Repeated measurements of plasma volume were made after two injections of Evans blue. Results were compared to deltaPV calculated from haematocrit (Hct) and blood haemoglobin concentration ([Hb]). Eight well-trained men completed four trials in randomized order: euhydration (control test C), 2.8% dehydration of body mass by passive controlled hyperthermia (D) and by treadmill exercise (60% of their maximal oxygen uptake, VO2max) (E), and hyperhydration (H) by glycerol ingestion. The Hct, [Hb], plasma protein concentrations and plasma osmolality were measured before, during and after the changes in body hydration. Different Hct and [Hb] reference values were obtained to allow for posture-induced variations between and during trials. The deltaPV values calculated after two Evans blue injections were in good agreement with deltaPV calculated from Hct and [Hb]. Compared to the control test, mean plasma volume declined markedly during heat-induced dehydration [-11.4 (SEM 1.7)%] and slightly during exercise-induced dehydration [-4.2 (SEM 0.9)%] (P < 0.001 compared to D), although hyperosmolality was similar in these two trials. Conversely, glycerol hyperhydration induced an increase in plasma volume [+7.5 (SEM 1.0)%]. These results would indicate that, for a given level of dehydration, plasma volume is dramatically decreased during and after heat exposure, while it is better maintained during and after exercise.
C Jimenez; B Melin; N Koulmann; A M Allevard; J C Launay; G Savourey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  80     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-22     Completed Date:  1999-07-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Unité de Bioénergétique et Environnement, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France.
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MeSH Terms
Blood Proteins / metabolism
Blood Volume / physiology*
Body Temperature Regulation / physiology
Dehydration / physiopathology*
Evans Blue / pharmacokinetics
Hot Temperature
Osmolar Concentration
Physical Exertion / physiology
Posture / physiology
Random Allocation
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins; 0/Vehicles; 314-13-6/Evans Blue; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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