Document Detail

Plasma vitamin C predicts incident heart failure in men and women in European Prospective Investigation into Cancer and Nutrition-Norfolk prospective study.
MedLine Citation:
PMID:  21835284     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Fruit and vegetable intake has been associated with lower risk for cardiovascular risk factors and disease, but data on heart failure are sparse and inconsistent. The association of plasma vitamin C, a biomarker reflecting fruit and vegetable intake, with heart failure has not been studied.
METHODS: We examined the prospective association of plasma vitamin C concentrations with incident fatal and nonfatal heart failure events in apparently healthy 9,187 men and 11,112 women aged 39 to 79 years participating in the "European Prospective Investigation into Cancer and Nutrition" study in Norfolk.
RESULTS: The risk of heart failure decreased with increasing plasma vitamin C; the hazard ratios comparing each quartile with the lowest were 0.76 (95% CI 0.65-0.88), 0.70 (95% CI 0.60-0.81), and 0.62 (95% CI 0.53-0.74) in age- and sex-adjusted analyses (P for trend <.0001). Every 20 μmol/L increase in plasma vitamin C concentration (1 SD) was associated with a 9% relative reduction in risk of heart failure after adjustment for age, sex, smoking, alcohol consumption, physical activity, occupational social class, educational level, systolic blood pressure, diabetes, cholesterol concentration, and body mass index, with similar result if adjusting for interim coronary heart disease.
CONCLUSIONS: Plasma vitamin C, a biomarker reflecting fruit and vegetable intake, was inversely associated with the risk of heart failure in this healthy population. This observation should be regarded as hypothesis generating for further prospective trials aimed at examining the effect of a diet rich in fruit and vegetables for prevention of heart failure.
Roman Pfister; Stephen J Sharp; Robert Luben; Nick J Wareham; Kay-Tee Khaw
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-07-07
Journal Detail:
Title:  American heart journal     Volume:  162     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-12     Completed Date:  2011-10-18     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-53     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
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MeSH Terms
Ascorbic Acid / blood*
Biological Markers / blood
Diet Surveys*
Disease Progression
Europe / epidemiology
Follow-Up Studies
Heart Failure / blood*,  epidemiology
Life Style
Middle Aged
Prospective Studies
Risk Factors
Grant Support
G0401527//Medical Research Council; G1000143//Medical Research Council; MC_U106179471//Medical Research Council
Reg. No./Substance:
0/Biological Markers; PQ6CK8PD0R/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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