Document Detail


Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus.
MedLine Citation:
PMID:  20059442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Visfatin, an adipocytokine, is a peptide predominantly expressed in and secreted from visceral adipose. In this study, we aimed to compare visfatin levels in gestational (GDM) and pre-gestational diabetic (pre-GDM) women with healthy pregnant women. We also sought to determine whether there was a correlation between visfatin levels and serum glucose levels at 1 h after the 50-g oral glucose challenge test in pregnant women with GDM and normal glucose tolerance.
METHODS: The study consisted of 65 pregnant women: 21 patients with GDM (Group 1), 20 patients with pre-GDM (Group 2) and 24 gestational age and BMI-matched healthy pregnant women (Group 3) were enrolled.
RESULTS: Plasma visfatin levels in Groups 1 and 2 were significantly higher than in Group 3 (P < 0.001). Plasma visfatin levels in Groups 1 and 2 were similar (P > 0.05). There was no significant correlation between visfatin levels and serum glucose levels at 1 h after the glucose tolerance test in both Groups 1 and 3 (P > 0.05).
CONCLUSIONS: Our results support the literature indicating higher visfatin levels in women with GDM compared to women with normal glucose tolerance. Interestingly, we found similarly high visfatin levels in women with pre-GDM.
Authors:
Ayhan Coskun; Mesut Ozkaya; Gurkan Kiran; Metin Kilinc; Deniz Cemgil Arikan
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1014-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey. acoskun@ksu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism*
Case-Control Studies
Diabetes, Gestational / blood*
Female
Gestational Age
Glucose Intolerance / blood
Glucose Tolerance Test
Humans
Insulin Resistance / physiology
Nicotinamide Phosphoribosyltransferase / blood*
Prediabetic State / blood*
Pregnancy
Pregnancy Complications / blood
Young Adult
Chemical
Reg. No./Substance:
0/Blood Glucose; EC 2.4.2.12/Nicotinamide Phosphoribosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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