| Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus. | |
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MedLine Citation:
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PMID: 20059442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Visfatin, an adipocytokine, is a peptide predominantly expressed in and secreted from visceral adipose. In this study, we aimed to compare visfatin levels in gestational (GDM) and pre-gestational diabetic (pre-GDM) women with healthy pregnant women. We also sought to determine whether there was a correlation between visfatin levels and serum glucose levels at 1 h after the 50-g oral glucose challenge test in pregnant women with GDM and normal glucose tolerance. METHODS: The study consisted of 65 pregnant women: 21 patients with GDM (Group 1), 20 patients with pre-GDM (Group 2) and 24 gestational age and BMI-matched healthy pregnant women (Group 3) were enrolled. RESULTS: Plasma visfatin levels in Groups 1 and 2 were significantly higher than in Group 3 (P < 0.001). Plasma visfatin levels in Groups 1 and 2 were similar (P > 0.05). There was no significant correlation between visfatin levels and serum glucose levels at 1 h after the glucose tolerance test in both Groups 1 and 3 (P > 0.05). CONCLUSIONS: Our results support the literature indicating higher visfatin levels in women with GDM compared to women with normal glucose tolerance. Interestingly, we found similarly high visfatin levels in women with pre-GDM. |
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Authors:
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Ayhan Coskun; Mesut Ozkaya; Gurkan Kiran; Metin Kilinc; Deniz Cemgil Arikan |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 1014-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey. acoskun@ksu.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism* Case-Control Studies Diabetes, Gestational / blood* Female Gestational Age Glucose Intolerance / blood Glucose Tolerance Test Humans Insulin Resistance / physiology Nicotinamide Phosphoribosyltransferase / blood* Prediabetic State / blood* Pregnancy Pregnancy Complications / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; EC 2.4.2.12/Nicotinamide Phosphoribosyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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