Document Detail


Plasma vasopressin, renin and catecholamines during nitroprusside-induced hypotension in the newborn lamb.
MedLine Citation:
PMID:  2696775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The circulating levels of vasopressin, catecholamines and renin activity before, during and following a 10-20% fall in mean arterial blood pressure induced by sodium nitroprusside were measured in six chronically catheterized lambs during the first week of life. No significant changes in pHa, PaO2, PaCO2, Plasma sodium or osmolality were observed during or following the infusion of sodium nitroprusside at an average of 12 g.kg-1.min-1 (table I). However, the fall in blood pressure at the end of 60 minutes infusion, was associated with significant increases in the plasma levels of vasopressin from a control value of 2.4 +/- 0.57 to a maximum of 35.1 +/- 16.3 pg/ml (p = .002), renin activity from 6.7 +/- 1.56 to 27.4 +/- 11.44 ng.ml-1.hr-1 (p = .003), and catecholamines from 189.3 +/- 42.15 to 543.3 +/- 100.52 pg.ml-1 (p = .0001). The increase in vasopressin is lower, while that of PRA was higher and catecholamines similar to those found in the ewe. Plasma renin activity (PRA) and catecholamine levels remained elevated for at least 30 minutes following the end of the infusion while the mean blood pressure rose significantly above control levels and remained elevated for twenty minutes. We speculate that the persistent elevated levels of vasoactive mediators are responsible for the prolonged rebound hypertension following the cessation of the nitroprusside infusion and is the result of an immaturity of either a feedback process or metabolism of the vasoactive mediators or a combination of both mechanisms. This rebound hypertension could have adverse effects particularly in the very immature neonate.
Authors:
A B Zubrow; S S Daniel; R I Stark; M K Husain; L S James
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  17     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-09     Completed Date:  1990-04-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  IM    
Affiliation:
Medical College of Pediatrics, Philadelphia, Pennsylvania.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn*
Blood Pressure / drug effects
Catecholamines / blood*
Disease Models, Animal
Ferricyanides / pharmacology*
Heart Rate / drug effects
Hypotension / blood,  chemically induced*
Nitroprusside / pharmacology*
Renin / blood*
Renin-Angiotensin System / drug effects
Sheep
Vasopressins / blood*
Grant Support
ID/Acronym/Agency:
HD 12737/HD/NICHD NIH HHS; HD 13063/HD/NICHD NIH HHS; HL 14218/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Ferricyanides; 11000-17-2/Vasopressins; 15078-28-1/Nitroprusside; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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