Document Detail

Plasma and urine catecholamine levels in cosmonauts during long-term stay on Space Station Salyut-7.
MedLine Citation:
PMID:  11542424     Owner:  NASA     Status:  MEDLINE    
The activity of the sympathetic adrenal system in cosmonauts exposed to a stay in space lasting for about half a year has so far been studied only by measuring catecholamine levels in plasma and urine samples taken before space flight and after landing. The device "Plasma 01", specially designed for collecting and processing venous blood from subjects during space flight on board the station Salyut-7 rendered it possible for the first time to collect and freeze samples of blood from cosmonauts in the course of a long-term 237-day space flight. A physician-cosmonaut collected samples of blood and urine from two cosmonauts over the period of days 217-219 of their stay in space. The samples were transported to Earth frozen. As indicators of the sympathetic adrenal system activity, plasma and urine concentrations of epinephrine and norepinephrine as well as urine levels of the catecholamine metabolites metanephrine, normetanephrine, and vanillylmandelic acid were determined before, during and after space flight. On days 217-219 of space flight plasma epinephrine and norepinephrine levels were slightly increased, yet not substantially different from normal. During stress situations plasma norepinephrine and epinephrine levels usually exhibit a manifold increase. On days 217-219 of space flight norepinephrine and epinephrine levels in urine were comparable with pre-flight values and the levels of their metabolites were even significantly decreased. All the parameters studied, particularly plasma norepinephrine as well as urine norepinephrine, normetanephrine, and vanillylmandelic acid, reached the highest values 8 days after landing. The results obtained suggest that, in the period of days 217-219 of the cosmonauts stay in space in the state of weightlessness, the sympathetic adrenal system is either not activated at all or there is but a slight activation induced by specific activities of the cosmonauts, whereas in the process of re-adaptation after space flight on Earth this system is considerably more markedly activated.
R Kvetnansky; N A Davydova; V B Noskov; M Vigas; I A Popova; A C Usakov; L Macho; A I Grigoriev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta astronautica     Volume:  17     ISSN:  0094-5765     ISO Abbreviation:  Acta Astronaut     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1999-12-06     Completed Date:  1999-12-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9890631     Medline TA:  Acta Astronaut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-6     Citation Subset:  S    
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Space Flight Mission:
Flight Experiment; Salyut 7 Project; long duration; manned
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MeSH Terms
Adrenal Glands / physiology*
Epinephrine / blood,  metabolism*,  urine
Metanephrine / metabolism,  urine
Norepinephrine / blood,  metabolism*,  urine
Normetanephrine / metabolism,  urine
Space Flight*
Sympathetic Nervous System / physiology
Time Factors
Vanilmandelic Acid / metabolism,  urine
Reg. No./Substance:
5001-33-2/Metanephrine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 55-10-7/Vanilmandelic Acid; 97-31-4/Normetanephrine

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