Document Detail

Plasma and urinary catecholamines in salt-sensitive idiopathic hypertension.
MedLine Citation:
PMID:  3281896     Owner:  NLM     Status:  MEDLINE    
Nineteen patients with normal renin idiopathic hypertension were arbitrarily classified as salt-sensitive or salt-resistant depending on whether their mean arterial pressure did or did not increase by 8% or more when sodium intake was increased. The responses of the two subsets and of five normal subjects to sodium intakes of 9, 109, and 249 mEq/day given for 7 days were as follows: The salt-sensitive subjects retained more sodium than normal and plasma or urinary norepinephrine did not decrease when they were given a high sodium intake; urinary dopamine was normal but did not increase normally when sodium intake was increased. The salt-resistant subjects excreted sodium normally and plasma and urinary norepinephrine was decreased by 30 and 37%, respectively, when they were given a high sodium intake; urinary dopamine was supernormal and did not increase further when sodium intake was increased. Cumulative sodium retention during the high sodium intake was directly related to the percentage of change in plasma norepinephrine in the hypertensive subjects, suggesting that renal adrenergic activity was a factor in the impaired sodium excretion in the salt-sensitive patients. Cumulative sodium retention and the percentage of change in plasma norepinephrine were inversely related to urinary dopamine in the hypertensive subjects, suggesting that increased formation of dopamine in renal and neural tissue in the salt-resistant subjects may have been responsible for the differences between the subsets in renal and adrenergic responses to a high sodium intake.(ABSTRACT TRUNCATED AT 250 WORDS)
J R Gill; G Güllner; C R Lake; D J Lakatua; G Lan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  11     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-17     Completed Date:  1988-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-9     Citation Subset:  IM    
Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
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MeSH Terms
Catecholamines / metabolism*
Dopamine / urine
Hypertension / metabolism*
Middle Aged
Norepinephrine / blood
Renin / blood
Sodium, Dietary / metabolism,  pharmacology*
Reg. No./Substance:
0/Catecholamines; 0/Sodium, Dietary; 51-41-2/Norepinephrine; EC

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