| Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. | |
| | |
MedLine Citation:
|
PMID: 22251368 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Please cite this paper as: Hawkins T, Roberts J, Mangos G, Davis G, Roberts L, Brown M. Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. BJOG 2012; DOI: 10.1111/j.1471-0528.2011.03232.x. Objective To examine the relationship between hyperuricaemia, haemoconcentration and maternal and fetal outcomes in hypertensive pregnancies. Design Retrospective analysis of a database of hypertensive pregnancies. Setting St George Hospital, a major obstetric unit in Australia. Population A cohort of 1880 pregnant women without underlying hypertension or renal disease, referred for management of pre-eclampsia or gestational hypertension. Methods Demographic, clinical and biochemical data at time of referral and delivery were collected for each pregnancy. Women were grouped according to diagnosis (pre-eclampsia or gestational hypertension) and logistic regression analysis was used to determine the relationship between uric acid, haemoglobin, haematocrit and adverse outcomes; an α level of P < 0.01 was used for statistical significance. Main outcome measures Composites of adverse maternal and fetal outcomes. Results In women with 'benign' GH (without proteinuria or any other maternal clinical feature of pre-eclampsia) gestation-corrected hyperuricaemia was associated with increased risk of a small-for-gestational-age infant (OR 2.5; 95% CI 1.3-4.8) and prematurity (OR 3.2; 95% CI 1.4-7.2), but not with adverse maternal outcome. In the whole cohort of hypertensive pregnant women (those with pre-eclampsia or gestational hypertension) the risk of adverse maternal outcome (OR 2.0; 95% CI 1.6-2.4) and adverse fetal outcome (OR 1.8; 95% CI 1.5-2.1) increased with increasing concentration of uric acid. Hyperuricaemia corrected for gestation provided additional strength to these associations. Haemoglobin and haematocrit were not associated with adverse pregnancy outcome. Conclusions Hyperuricaemia in hypertensive pregnancy remains an important finding because it identifies women at increased risk of adverse maternal and particularly fetal outcome; the latter, even in women with gestational hypertension without any other feature of pre-eclampsia. |
| | |
Authors:
|
Tl-A Hawkins; Jm Roberts; Gj Mangos; Gk Davis; Lm Roberts; Ma Brown |
Related Documents
:
|
21749748 - Fetal outcome and amniocentesis results in pregnancies complicated by varicella infection. 22248988 - Protocol for measurement of mean arterial pressure at 11-13 weeks' gestation. 668078 - Reentry within the his-purkinje system. elucidation of reentrant circuit using right bu... 21726928 - Replacing gnrh agonists with gnrh antagonists in oocyte recipient cycle did not adverse... 1321998 - Cytologic diagnosis of human papillomavirus. influence of age and pregnancy stage. 7107318 - Dietary survey during pregnancy in a low socio-economic group. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
|
Title: BJOG : an international journal of obstetrics and gynaecology Volume: - ISSN: 1471-0528 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100935741 Medline TA: BJOG Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG. |
Affiliation:
|
Departments of Medicine and Obstetrics and Gynaecology, University of Calgary, Alberta, Canada Departments of Renal Medicine and Medicine, St George Hospital and University of New South Wales, Kogarah, NSW, Australia Department of Obstetrics, Gynaecology and Reproductive Sciences, and Epidemiology, Magee-Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, USA Department of Women's and Children's Health, St George Hospital, Kogarah, NSW, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Species-specific DNA probe and development of a quantitative PCR assay for the detection of Morganel...
Next Document: Examining "success" in post-hip fracture care transitions: A strengths-based approach.