| Plasma tumor necrosis factor soluble receptors in chronic renal failure. | |
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MedLine Citation:
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PMID: 1328755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two soluble tumor necrosis factor receptors (sTNFRs) were detected in the plasma of patients with different degrees of chronic renal failure (CRF) and of long-term hemodialysis (HD) patients. In uremic undialyzed patients, plasma levels of both sTNFRs increased progressively with declining renal function. A linear correlation was found between sTNFR plasma levels and plasma creatinine concentration. sTNFR levels in end-stage uremic patients shortly before commencement of first HD treatment were approximately tenfold higher than in normal subjects. Long-term HD patients showed a further increase in plasma sTNFRs. The origin of sTNFRs, as well as their physiological role remains to be elucidated. |
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Authors:
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M Brockhaus; Y Bar-Khayim; S Gurwicz; A Frensdorff; N Haran |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kidney international Volume: 42 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-11-06 Completed Date: 1992-11-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 663-7 Citation Subset: IM |
Affiliation:
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Central Research Units F., Hoffmann-La Roche Ltd., Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Immunoassay Kidney / physiopathology Kidney Failure, Chronic / blood*, physiopathology, therapy Male Middle Aged Osmolar Concentration Receptors, Cell Surface / metabolism* Receptors, Tumor Necrosis Factor Renal Dialysis Solubility Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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