Document Detail

Plasma tryptophan levels and tryptophan/neutral amino acid ratios in obsessive-compulsive patients with and without depression.
MedLine Citation:
PMID:  9080540     Owner:  NLM     Status:  MEDLINE    
We have studied fasting plasma tryptophan (TRP) levels and tryptophan/large neutral amino acid (TRP/LNAA) ratios in 12 patients with obsessive-compulsive disorder (OCD) and 12 patients with OCD and a coexisting current diagnosis of major depressive disorder (OCD-MDD). Assessments were made at baseline and after 6 weeks of treatment with fluvoxamine. OCD-MDD patients had significantly lower baseline TRP levels and TRP/LNAA ratios than OCD patients. After 6 weeks of fluvoxamine treatment, OCD-MDD patients had significant increases in plasma TRP and TRP/LNAA ratio, whereas OCD patients had non-significant decreases. Our data suggest that a major depressive syndrome could be a state variable affecting the changes in plasma TRP and TRP/LNAA ratio in OCD patients.
L Bellodi; S Erzegovesi; L Bianchi; V Lucini; R Conca; A Lucca
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Psychiatry research     Volume:  69     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-30     Completed Date:  1997-05-30     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Italy.
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MeSH Terms
Depressive Disorder / blood*,  complications*,  drug therapy
Fluvoxamine / administration & dosage,  therapeutic use
Middle Aged
Obsessive-Compulsive Disorder / blood*,  complications*,  drug therapy
Retrospective Studies
Serotonin Uptake Inhibitors / administration & dosage,  therapeutic use
Tryptophan / blood*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine; 73-22-3/Tryptophan

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