Document Detail

Plasma total thyroxine and free thyroxine concentrations in congenital hypothyroidism before and during treatment.
MedLine Citation:
PMID:  1401216     Owner:  NLM     Status:  MEDLINE    
AIMS: To examine the relation between plasma total thyroxine and free thyroxine in children with congenital hypothyroidism. METHODS: Regression analysis was performed on 114 cases on the paired total thyroxine and free thyroxine measurements taken from the same blood sample. Conversion equations were derived using structural relation models. RESULTS: A linear relation was found between log total thyroxine and log free thyroxine values. The regression slopes for values taken before treatment and values taken while patients were receiving replacement treatment were significantly different. CONCLUSIONS: The data suggest that there is a close association between total and free thyroxine in congenital hypothyroidism, but that the relation is changed by thyroid replacement treatment.
S L Tillotson; D B Grant; A E Ades
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  45     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-09     Completed Date:  1992-11-09     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  819-20     Citation Subset:  AIM; IM    
Medical Unit, Institute of Child Health, London.
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MeSH Terms
Congenital Hypothyroidism*
Hypothyroidism / blood*,  drug therapy
Regression Analysis
Thyroxine / blood*,  therapeutic use
Reg. No./Substance:

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