Document Detail

Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study.
MedLine Citation:
PMID:  10731504     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Total homocysteine (tHcy) measured in serum or plasma is a marker of folate status and a risk factor for cardiovascular disease. OBJECTIVE: Our objective was to investigate associations between tHcy and complications and adverse outcomes of pregnancy. DESIGN: Plasma tHcy values measured in 1992-1993 in 5883 women aged 40-42 y were compared with outcomes and complications of 14492 pregnancies in the same women that were reported to the Medical Birth Registry of Norway from 1967 to 1996. RESULTS: When we compared the upper with the lower quartile of plasma tHcy, the adjusted risk for preeclampsia was 32% higher [odds ratio (OR): 1. 32; 95% CI: 0.98, 1.77; P for trend = 0.02], that for prematurity was 38% higher (OR: 1.38; 95% CI: 1.09, 1.75; P for trend = 0.005), and that for very low birth weight was 101% higher (OR: 2.01; 95% CI: 1.23, 3.27; P for trend = 0.003). These associations were stronger during the years closest to the tHcy determination (1980-1996), when there was also a significant relation between tHcy concentration and stillbirth (OR: 2.03; 95% CI: 0.98, 4.21; P for trend = 0.02). Neural tube defects and clubfoot had significant associations with plasma tHcy. Placental abruption had no relation with tHcy quartile, but the adjusted OR when tHcy concentrations >15 micromol/L were compared with lower values was 3.13 (95% CI: 1.63, 6. 03; P = 0.001). CONCLUSION: Elevated tHcy concentration is associated with common pregnancy complications and adverse pregnancy outcomes.
S E Vollset; H Refsum; L M Irgens; B M Emblem; A Tverdal; H K Gjessing; A L Monsen; P M Ueland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  71     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-20     Completed Date:  2000-04-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  962-8     Citation Subset:  AIM; IM    
Section for Medical Statistics, the Department of Public Health and Primary Health Care, Norway.
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MeSH Terms
Abruptio Placentae / blood
Biological Markers / blood*
Clubfoot / blood
Congenital Abnormalities / blood
Fetal Death / blood
Fetal Growth Retardation / blood
Folic Acid Deficiency / blood
Homocysteine / blood*
Infant, Newborn
Infant, Very Low Birth Weight
Middle Aged
Neural Tube Defects / blood
Obstetric Labor, Premature / blood
Pre-Eclampsia / blood
Pregnancy Complications / blood*
Pregnancy Outcome*
Risk Factors
Reg. No./Substance:
0/Biological Markers; 454-28-4/Homocysteine
Comment In:
Am J Clin Nutr. 2000 Apr;71(4):857-8   [PMID:  10731488 ]

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