Document Detail

Plasma total homocysteine: instigator or indicator of cardiovascular disease?
MedLine Citation:
PMID:  18583617     Owner:  NLM     Status:  MEDLINE    
Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. However, traditional risk factors cannot fully account for this. In the last 20 years, there has been an explosion of interest in plasma total homocysteine (tHcy) as a potential modifiable risk factor for CVD. Recent meta-analyses of epidemiological studies support the concept that increased tHcy concentrations are associated with CVD. This has led to the 'homocysteine hypothesis', which states that lowering plasma tHcy using folic acid and other B-vitamins will reduce the risk of CVD. In experimental studies, homocysteine has been shown to cause oxidative stress, endothelial cell dysfunction and promote thrombogenesis. However, data from recent large randomized controlled trials have shown that there is no clinical benefit to lowering plasma tHcy concentrations with folic acid and other B-vitamins. This lack of effect of tHcy lowering strongly suggests that homocysteine is not an instigator but merely an indicator of CVD.
Stuart J Moat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  45     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  345-8     Citation Subset:  IM    
Department of Medical Biochemistry and Immunology, University Hospital of Wales and Wales College of Medicine, Heath Park, Cardiff CF14 4XW, UK.
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MeSH Terms
Biological Markers / blood
Cardiovascular Diseases / blood*,  diagnosis*,  etiology
Folic Acid / pharmacology
Homocysteine / blood*
Inflammation / blood
Risk Factors
Grant Support
//British Heart Foundation; //Wellcome Trust
Reg. No./Substance:
0/Biological Markers; 454-28-4/Homocysteine; 59-30-3/Folic Acid

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