Document Detail


Plasma and tissue levels of collagen types I and III markers in patients with abdominal aortic aneurysms.
MedLine Citation:
PMID:  10853688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To study the levels of the aminoterminal propeptide of type III(PIIINP) and carboxyterminal propeptide of type I procollagen (PICP) in plasma and in the wall of abdominal aortic aneurysms in relation to their size and symptomatology. PIIINP serves as a marker of turnover and PICP as a marker of the synthesis of the corresponding collagens.
METHODS:
EXPERIMENTAL DESIGN: A prospective non-randomised study.
SETTING: University Hospital, Plzen, Czech Republic.
PATIENTS: Eighty-six patients who underwent resection of abdominal aortic aneurysms, average age 70.1 years (range 45 to 91 years), men to women ratio 5:1. The indication for resection was its symptomatology without relation to its diameter, and diameter over 5 cm in asymptomatic patients. Twenty patients (with similar age and gender distribution) scheduled for hernia repair or laparoscopic cholecystectomy were examined as a control group.
MAIN OUTCOME MEASURES: The plasma and tissue PICP and PIIINP concentrations were evaluated using radioimmunoassay methods. The plasma samples were taken from the cubital vein without the use of a tourniquet. Full-thickness sections of the anterior abdominal aortic aneurysm wall at the site of the largest aneurysm diameter were taken at the time of operation.
RESULTS: A significant difference between plasma PIIINP levels in patients with abdominal aortic aneurysms and the control group was observed (p<0.01). No correlation of PICP, PIIINP plasma levels with diameter and symptomatology of abdominal aortic aneurysms was found. The increase in PHIIINP tissue concentration was significant in patients with increasing diameter and positive symptomatology (p<0.01). No statistically significant correlation between plasma and tissue PICP and PIIINP concentrations was observed.
CONCLUSIONS: The metabolism of type III collagen is increased in patients with abdominal aortic aneurysm, in contrast to type I collagen. The result is a degradation of collagen in the aneurysmal wall. The turnover of type III collagen increases with the enlargement of the aneurysm diameter and with the positive symptomatology. Degradation of type III collagen in the aneurysmal wall has therefore a fundamental significance for abdominal aortic aneurysm rupture. Because no correlation between plasma and tissue levels of PIIINP was found, the plasma levels of PIIINP cannot be used as the plasma markers of this process.
Authors:
V Treska; O Topolcan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  19     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-10-03     Completed Date:  2000-10-03     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aorta, Abdominal / metabolism*
Aortic Aneurysm, Abdominal / metabolism*
Biological Markers
Female
Humans
Male
Middle Aged
Peptide Fragments / blood*,  metabolism
Procollagen / blood*,  metabolism
Prospective Studies
Radioimmunoassay
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/Procollagen; 0/procollagen Type III-N-terminal peptide; 0/procollagen type I carboxy terminal peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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