Document Detail


Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis.
MedLine Citation:
PMID:  17223726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue factor is a cell surface protein that is expressed constitutively by monocytes, macrophages and fibroblasts, but also by some other cells in response to a variety of stimuli. The main function of the tissue factor is to form a complex with factor VII/VIIa that converts factors IX and X to their active forms. Tissue factor is also involved in the pathophysiology of systemic inflammatory disorders, coagulopathies, atherosclerotic disease, tumor angiogenesis and metastasis. Increased tissue factor expression either locally in the coronary plaques or systematically on circulating blood elements of patients with acute coronary syndromes may be responsible for increased thrombin generation, thus leading to platelet activation and fibrin formation. Tissue factor therefore plays a pivotal role in the initiation of thrombotic complications in patients with coronary artery disease.
Authors:
J Vojácek; J Dusek; J Bis; J Stásek; M Blazek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-02
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  57     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-16     Completed Date:  2008-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
First Department Medicine, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Czech Republic. vojacjan@fnhk.cz
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / metabolism
Coronary Artery Disease / blood*
Coronary Thrombosis / blood*
Humans
Thromboplastin / metabolism*
Chemical
Reg. No./Substance:
0/Biological Markers; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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