| Plasma thyroid hormones in premature infants: effect of gestational age and antenatal thyrotropin-releasing hormone treatment. TRH Collaborative Trial Participants. | |
| | |
MedLine Citation:
|
PMID: 9803444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thyroid hormones are important for both perinatal adaptation and long-term psychomotor development; however, there is limited information on the effects of extreme prematurity and antenatal TSH-releasing hormone (TRH) treatment on pituitary-thyroid function. In this study we assayed plasma triiodothyronine (T3) and TSH in infants who were part of a collaborative trial of antenatal maternal TRH therapy. Within the control population (n = 166), infants of 24-28-wk and 28-32-wk gestational age had comparable levels of T3 (0.94 and 1.06 nmol/L, respectively) and TSH (5.7 and 7.2 mU/L) at birth, but the increases at 2 h and subsequent T3 levels were less in the 24-28 wk versus 28-32-wk gestation infants. In the TRH-treated group (n = 131), T3 was lower in the first day for infants delivered 7-72 h after antenatal TRH compared with control infants. TSH at birth was approximately 3.5-fold greater for infants delivered at 0-6 h after the last TRH dose compared with the control group and was suppressed in infants delivering at 7-36 h. T3 and TSH levels were not different between control and TRH-treated groups at 3-28 d of age. In TRH stimulation tests on d 28, control and TRH-treated groups had similar peak levels of TSH and incidence of exaggerated response (TSH > or = 35 mU/L). We conclude that extremely premature infants have a reduced postnatal surge in TSH and T3 and maintain lower T3 concentrations, probably reflecting tertiary hypothyroidism. The stimulatory and suppressive effects of antenatal TRH treatment observed at birth are transient and do not affect pituitary-thyroid responsiveness at 28 d of age. |
| | |
Authors:
|
P L Ballard; R A Ballard; Y Ning; A Cnann; C Boardman; J Pinto-Martin; D Polk; R H Phibbs; D J Davis; F L Mannino; M Hart |
Related Documents
:
|
4504334 - Gyrinidal: a sesquiterpenoid aldehyde from the defensive glands of gyrinid beetles. 15181064 - The hypothalamic-pituitary-thyroid axis in preterm infants; changes in the first 24 hou... 19787174 - Evaluation of thyroid status of infants in the intensive care setting. 7189054 - Effects of methadone on thyroid function in mother, fetus, and newborn. 8879064 - Current and future impact of rising multiple birth ratios on low birthweight. 12453154 - A new yeast endosomal snare related to mammalian syntaxin 8. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Pediatric research Volume: 44 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1998 Nov |
Date Detail:
|
Created Date: 1999-01-12 Completed Date: 1999-01-12 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 642-9 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Pennsylvania, Philadelphia 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Congenital Hypothyroidism* Gestational Age* Humans Hypothyroidism / drug therapy Infant, Newborn Infant, Premature / blood* Infant, Premature, Diseases / drug therapy* Prenatal Diagnosis Thyroid Hormones / blood* Thyrotropin / blood Thyrotropin-Releasing Hormone / therapeutic use* Triiodothyronine / blood |
| Grant Support | |
ID/Acronym/Agency:
|
MO1-RR00040/RR/NCRR NIH HHS; MO1-RR000425/RR/NCRR NIH HHS; R01 HD 29201/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Thyroid Hormones; 24305-27-9/Thyrotropin-Releasing Hormone; 6893-02-3/Triiodothyronine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Creatinine reabsorption by the newborn rabbit kidney.
Next Document: Development of a highly sensitive nonisotopic immunoassay for the determination of salivary 17-hydro...