Document Detail

Plasma thrombomodulin levels in coronary sinus blood in patients with coronary artery disease.
MedLine Citation:
PMID:  7605878     Owner:  NLM     Status:  MEDLINE    
Plasma thrombomodulin (TM) levels in coronary sinus blood were measured in 15 patients with coronary artery disease who underwent elective PTCA (group A). TM was also measured in eight patients with coronary artery disease (group B) and six patients without coronary artery disease (group C), who only underwent diagnostic coronary angiography. The baseline level was 21.6 +/- 3.4 U/ml in group A, and 21.0 +/- 4.9 in group B, and both levels were slightly higher (P < 0.05) than those in group C (15.1 +/- 3.3). In group A, the level increased to 27.5 +/- 8.3 (P < 0.01) immediately after PTCA and then returned to 22.2 +/- 5.1 by 24 h. In groups B and C, levels showed no change immediately after angiography. In group A, the percentage increase in the TM level immediately after PTCA from that before the procedure correlated with the number of balloon inflations (r = 0.76, P < 0.01). In conclusion, the plasma TM level in coronary sinus blood might indicate endothelial damage due to atherosclerotic coronary artery disease and an increase in the level after PTCA might directly indicate vascular injury by balloon inflation.
K Hoshi; T Inoue; H Kakoi; T Satoh; H Yamaguchi; Y Sakai; S Morooka; Y Takabatake
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  6     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-17     Completed Date:  1995-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitana, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Circulation / physiology*
Coronary Disease / blood,  pathology,  therapy*
Endothelium, Vascular / pathology
Evaluation Studies as Topic
Middle Aged
Sinus of Valsalva
Thrombomodulin / metabolism*
Reg. No./Substance:

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