| Plasma theophylline concentrations and airway function in asthmatic children receiving standard and modified RTC therapy. | |
| | |
MedLine Citation:
|
PMID: 1634448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of three different dosage schedules for sustained-release theophylline (Theolong) were investigated in children with asthma. With regimen II (unequal doses at 0800 h and 2000 h), the maximum plasma theophylline concentration following the evening dose was significantly higher than that following the morning dose, and also was larger than that following the evening dose with regimen I (equal doses at 0800 and 2000 h). With regimen III (equal doses at 0600 h and 2100 h), the mean theophylline concentration-time curve showed a single large peak at 1100 h, whereas with regimen I, there were two peaks at 2300 and at 1400 h. Knowledge that a change of the dosage schedule can affect the pharmacokinetics of theophylline in this way should aid physicians in its safe and effective use. |
| | |
Authors:
|
H Arakawa; A Morikawa; M Shigeta; M Kato; T Kuroume; T Kimura; K Tateno |
Related Documents
:
|
14728988 - The rate of de novo galactose synthesis in patients with galactose-1-phosphate uridyltr... 8813608 - Theophylline-induced grooming: possible indirect dopaminergic mechanism. 11554438 - Dose dependent pharmacokinetics of theophylline: michaelis-menten parameters for its ma... 6668628 - Thallium poisoning--toxin elimination and therapy in three cases. 2896238 - Increment of calmodulin in proportion to enhancement of non-nicotinic responses after p... 17509918 - Changes in haptoglobin, c-reactive protein and pig-map during a housing period followin... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 29 ISSN: 0277-0903 ISO Abbreviation: J Asthma Publication Date: 1992 |
Date Detail:
|
Created Date: 1992-08-27 Completed Date: 1992-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8106454 Medline TA: J Asthma Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 235-43 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Gunma University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Asthma
/
blood,
drug therapy* Child Circadian Rhythm / physiology* Delayed-Action Preparations Drug Administration Schedule Female Humans Male Theophylline / administration & dosage*, blood, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cryopreservative effect of leupeptin on early human bone marrow progenitors.
Next Document: Effect of ibudilast: a novel antiasthmatic agent, on airway hypersensitivity in bronchial asthma.