Document Detail

Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters.
MedLine Citation:
PMID:  22715479     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress.
DESIGN: Prospective study.
METHODS: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (s.d.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined.
RESULTS: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values.
CONCLUSIONS: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.
Tania Siahanidou; Maria Garatzioti; Christina Lazaropoulou; Georgia Kourlaba; Ioannis Papassotiriou; Tomoshige Kino; Akihiro Imura; Yo-ichi Nabeshima; George Chrousos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-19
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  167     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  2012-11-01     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM    
First Department of Pediatrics, Athens University Medical School, Athens, Greece.
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MeSH Terms
Age Factors
Biological Markers / blood
Child Development / physiology*
Energy Metabolism / physiology*
Glucuronidase / blood*
Infant, Newborn
Infant, Premature / blood*,  growth & development*
Oxidative Stress / physiology*
Grant Support
Reg. No./Substance:
0/Biological Markers; EC; EC protein

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