Document Detail

Plasma sialic acid alterations in neoplastic diseases.
MedLine Citation:
PMID:  3505259     Owner:  NLM     Status:  MEDLINE    
The several types of neoplastic transformations are accompanied by alterations in the composition of cell glycoproteins, which are major structural components of cell surfaces. One such observed alteration is in the level of sialic acid on the cell surface. In the present investigation, plasma sialic acid levels were measured in normal volunteers and neoplastic patients using thiobarbituric acid spectrophotometric methods. The mean plasma sialic acid level from 124 normal volunteers was 3.0 mumol/ml. The mean for 20 non-malignant patients was 3.2 mumol/ml. Such observed mean values of sialic acid were 3.7 mumol/ml in 64 breast cancer patients, 5.1 mumol/ml in 22 lung cancer patients, 4.1 mumol/ml in 20 colon patients, and 5.0 mumol/ml in 26 patients having ovarian, cervix, pancreas, prostate, thyroid, uterine, squamous cell, esophageal and endometrial cancers. Serial determinations of plasma sialic acid in 15 patients correlated well with the progression and regression of disease. These results indicate that plasma sialic acid levels are elevated over control levels in the different types of cancer patients studied. Assay of plasma sialic acid is not sensitive enough to be used for screening, but could be used as a prognostic determinant in a variety of neoplastic conditions.
C Dwivedi; M Dixit; S S Kumar; H Reddy; K A Semenya; R E Hardy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medicine     Volume:  18     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  1987  
Date Detail:
Created Date:  1989-02-22     Completed Date:  1989-02-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-32     Citation Subset:  IM    
College of Pharmacy, South Dakota State University, Brookings 57007.
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MeSH Terms
Age Factors
Breast Neoplasms / blood
Colonic Neoplasms / blood
Lung Neoplasms / blood
Neoplasms / blood*,  diagnosis
Reference Values
Sialic Acids / blood*
Spectrophotometry / methods
Tumor Markers, Biological / blood*
Grant Support
Reg. No./Substance:
0/Sialic Acids; 0/Tumor Markers, Biological

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