| Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. | |
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MedLine Citation:
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PMID: 9578818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In humans a sexual dimorphism of plasma leptin concentration has been demonstrated but its significance remains to be established. Sex hormones may have a role. PATIENTS: Eighty healthy, non-obese subjects (41M/39F) were studied. MEASUREMENTS: In the whole group of subjects plasma sex hormones, leptin and insulin concentrations were determined, body fat content assessed by bioimpedance analysis, body fat distribution evaluated and insulin-mediated glucose uptake measured by euglycemic hyperinsulinemic glucose. RESULTS: After adjustment for age, gender, amount of body fat, waist/hip ratio (WHR) and fasting plasma insulin concentration, fasting plasma leptin was still significantly correlated with plasma DHEAS (r = -0.30, P < 0.006), oestradiol (r = 0.53, P < 0.001) and testosterone (r = -0.43, P < 0.001) in all subjects (n = 80). Independently of age, amount of body fat and WHR, fasting plasma leptin concentration correlated with plasma oestradiol (r = 0.38, P < 0.01) and total testosterone (r = -0.58, P < 0.001) in males (n = 41) and with fasting plasma oestradiol (r = 0.48, P < 0.002) in females (n = 39). To investigate the independent contribution of anthropometric and hormonal variables to fasting plasma leptin concentration, a multivariate stepwise regression analysis with fasting plasma leptin concentration as dependent variable was made. In the entire group (n = 80), the whole model explained 43% of fasting plasma leptin concentration with fasting plasma insulin, total testosterone and oestradiol concentrations significantly and independently associated with plasma leptin concentration. In this model, fasting plasma DHEAS, testosterone and oestradiol explained 25% of the variability in plasma leptin concentration. CONCLUSION: Our study demonstrates that plasma sex hormone concentrations are associated with plasma leptin concentration. |
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Authors:
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G Paolisso; M R Rizzo; C M Mone; M R Tagliamonte; A Gambardella; M Riondino; C Carella; M Varricchio; F D'Onofrio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical endocrinology Volume: 48 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-21 Completed Date: 1998-05-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 291-7 Citation Subset: IM |
Affiliation:
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Department of Geriatric Medicine and Metabolic diseases, University of Naples, Italy. gpaoliss@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Body Constitution Cross-Sectional Studies Dehydroepiandrosterone Sulfate / blood Estradiol / blood Female Gonadal Steroid Hormones / blood* Humans Insulin / blood* Leptin Male Middle Aged Proteins / analysis* Regression Analysis Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Gonadal Steroid Hormones; 0/Leptin; 0/Proteins; 11061-68-0/Insulin; 50-28-2/Estradiol; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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