Document Detail

Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases.
MedLine Citation:
PMID:  2970389     Owner:  NLM     Status:  MEDLINE    
To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-right shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r = 0.95, P less than 0.001), mean pulmonary arterial pressure (r = 0.74, P less than 0.001) and right atrial pressure (r = 0.53, P less than 0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.
K Akimoto; A Miyata; K Kangawa; H Matsuo; Y Koga; Y Matsuoka; K Hayakawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  147     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-29     Completed Date:  1988-09-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
Department of Paediatrics, Miyazaki Medical College, Japan.
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MeSH Terms
Atrial Natriuretic Factor / blood,  metabolism*
Child, Preschool
Heart Atria
Heart Defects, Congenital / blood,  metabolism*
Myocardium / metabolism*
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

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