Document Detail


Plasma resistin associated with myocardium injury in patients with acute coronary syndrome.
MedLine Citation:
PMID:  18654008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Resistin, a novel adipocytokine, has been suggested as representing a link between metabolic signals, inflammation and atherosclerosis. The aim of the present study was to investigate the alteration in level of plasma resistin in patients with acute coronary syndrome (ACS) to uncover the role of resistin. METHODS AND RESULTS: The 39 patients with ACS and 26 age-matched healthy subjects in this cross-sectional study were investigated. Plasma resistin levels were measured using radioimmunoassay. Plasma resistin levels were significantly increased in patients with ACS at 24 h after symptoms onset and remained at a high level for 1 week, and were significantly higher in patients with acute myocardial infarction than in those with unstable angina. In addition, plasma resistin level was correlated positively with peak plasma creatine kinase (CK), the MB isoform of CK and troponin I, and was correlated negatively with left ventricular ejection fraction. No correlation was found between plasma resistin level with level of metabolic parameters or inflammatory markers. CONCLUSIONS: Plasma resistin levels in patients with ACS are elevated significantly within the first week after symptoms onset. Increased resistin levels may be a marker of myocardial ischemia and injury in ACS.
Authors:
Songyun Chu; Wenhui Ding; Kang Li; Yongzheng Pang; Chaoshu Tang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1249-53     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Peking University First Hospital, Peking University Health Science Center, Beijing, Peoples Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*,  pathology,  physiopathology
Aged
Angina, Unstable / blood,  pathology
Biological Markers / blood
Case-Control Studies
Creatine Kinase, MB Form / blood
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Myocardial Infarction / blood,  pathology
Myocardium / pathology*
Resistin / blood*
Stroke Volume
Time Factors
Troponin I / blood
Up-Regulation
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Biological Markers; 0/RETN protein, human; 0/Resistin; 0/Troponin I; EC 2.7.3.2/Creatine Kinase, MB Form

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