Document Detail

Plasma renin predicts success of antihypertensive drug withdrawal.
MedLine Citation:
PMID:  7986457     Owner:  NLM     Status:  MEDLINE    
This study examined the relationship of plasma renin activity (PRA) to the likelihood of maintaining blood pressure control after discontinuation of antihypertensive medication. Patients whose blood pressure was previously treated and controlled in the Hypertension Detection and Follow-up Program were enrolled in the Dietary Intervention Study of Hypertension. After stratification by obesity, patients were randomized to discontinue medication with no dietary intervention, sodium restriction, or weight reduction for the obese. Among 496 subjects in the Dietary Intervention Study of Hypertension, 75 were randomly selected for PRA measurement at 4 months after intervention, and all had their blood pressure under control at that time. Patients were followed up for 56 weeks after randomization. The endpoint was return to antihypertensive medication due to elevated diastolic blood pressure. Kaplan-Meier survival analysis showed that subjects with PRA < or = 53.3 ng/100 mL/h, the median level, had a lower cumulative success rate for remaining off antihypertensive drug than those with PRA above the median (P = .046). In Cox regression analysis controlling for 24-h urinary sodium level, baseline diastolic blood pressure, age, sex, race, obesity, and dietary intervention group, a unit decrease in log PRA was associated with a 2.78-fold increase in risk of returning to drug (P = .006); this inverse relationship was independent of dietary intervention and change in diastolic blood pressure in the first 4 months before PRA was measured. The data indicate that patients with low PRA are less likely to maintain blood pressure control without drugs than patients with high PRA.
G Y Ho; M D Blaufox; S Wassertheil-Smoller; A Oberman; H Langford
Related Documents :
11879247 - Online hemodiafiltration versus acetate-free biofiltration: a prospective crossover study.
6609507 - Contraceptive pill use, urinary sodium and blood pressure. a population study in two be...
15174897 - The epithelial sodium channel in hypertension: genetic heterogeneity and implications f...
891207 - Role of sodium and water in hypertensive patients on maintenance hemodialysis.
6545937 - Acute physiological responses of squirrel monkeys exposed to hyperdynamic environments.
16287427 - What role do adrenoreceptor polymorphisms play in modifying cardiovascular responses in...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  7     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-12     Completed Date:  1995-01-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  679-84     Citation Subset:  IM    
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Analysis of Variance
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Diet, Reducing*
Diet, Sodium-Restricted*
Follow-Up Studies
Hypertension / diet therapy,  drug therapy*
Middle Aged
Potassium / administration & dosage
Regression Analysis
Renin / blood*
Risk Factors
Sex Factors
Sodium / urine
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents; 7440-09-7/Potassium; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation and treatment of bacterial microleakage.
Next Document:  Life style as a determinant of blood pressure in the general population.