Document Detail

Plasma renin activity responses to graded decreases in renal perfusion pressure in fetal and newborn lambs.
MedLine Citation:
PMID:  1558222     Owner:  NLM     Status:  MEDLINE    
We examined the relationship between acute reductions in renal perfusion pressure, as approximated by femoral arterial blood pressure, and plasma renin activity in the uninephrectomized fetal lamb. Renal perfusion pressure was reduced and maintained at a constant value by controlled partial occlusion of the aorta above the renal artery. After 15 min of reduced blood pressure, blood samples were taken for determination of plasma renin activity. This protocol was performed 22 times in 11 fetal lambs. Additionally, three of the fetuses were delivered by cesarean section and studied as newborns for the first week of life. In the fetus, there was a linear relationship between log plasma renin activity and femoral arterial blood pressure (P less than 0.01). After birth, the relationship still existed, although it was shifted to the right (P less than 0.0001). We conclude that there is a significant relationship between plasma renin activity and renal perfusion pressure in the fetal lamb, and as early as 1 day after birth, this relationship shifts to the right in the newborn lamb.
N D Binder; D F Anderson
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  262     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-04     Completed Date:  1992-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R524-9     Citation Subset:  IM    
Department of Pediatrics and Physiology, Oregon Health Sciences University, Portland 97201-3098.
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MeSH Terms
Analysis of Variance
Animals, Newborn
Blood Flow Velocity
Blood Pressure*
Carotid Arteries / embryology,  physiology
Femoral Artery / embryology,  physiology
Kidney / embryology,  physiology
Renal Circulation*
Renin / blood*
Grant Support
Reg. No./Substance:

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