| Plasma renin activity responses to graded decreases in renal perfusion pressure in fetal and newborn lambs. | |
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MedLine Citation:
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PMID: 1558222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the relationship between acute reductions in renal perfusion pressure, as approximated by femoral arterial blood pressure, and plasma renin activity in the uninephrectomized fetal lamb. Renal perfusion pressure was reduced and maintained at a constant value by controlled partial occlusion of the aorta above the renal artery. After 15 min of reduced blood pressure, blood samples were taken for determination of plasma renin activity. This protocol was performed 22 times in 11 fetal lambs. Additionally, three of the fetuses were delivered by cesarean section and studied as newborns for the first week of life. In the fetus, there was a linear relationship between log plasma renin activity and femoral arterial blood pressure (P less than 0.01). After birth, the relationship still existed, although it was shifted to the right (P less than 0.0001). We conclude that there is a significant relationship between plasma renin activity and renal perfusion pressure in the fetal lamb, and as early as 1 day after birth, this relationship shifts to the right in the newborn lamb. |
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Authors:
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N D Binder; D F Anderson |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 262 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-05-04 Completed Date: 1992-05-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R524-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Physiology, Oregon Health Sciences University, Portland 97201-3098. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Blood Flow Velocity Blood Pressure* Carotid Arteries / embryology, physiology Diuresis Female Femoral Artery / embryology, physiology Fetus Homeostasis Kidney / embryology, physiology Pregnancy Renal Circulation* Renin / blood* Sheep |
| Grant Support | |
ID/Acronym/Agency:
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HD-10034/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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