Document Detail

Plasma renin activity in sheep pregnancy after fetal or maternal nephrectomy.
MedLine Citation:
PMID:  861318     Owner:  NLM     Status:  MEDLINE    
The effect of bilateral fetal or maternal nephrectomy on basal and diuretic-stimulated plasma renin activity (Pra) was examined in 9 chronically catheterized Dorset sheep. After fetal nephrectomy, there was an initial rapid decrease in fetal PRA with t1/2 of 42-84 min, followed by a slower decrement with 1/2 350-720 min. There was no change in maternal PRA during this period. Similarly, after maternal nephrectomy, the decrease in maternal PRA had two exponential components and there was no associated change in fetal PRA. These data, and the maternal and fetal PRA responses to intravenous furosemide, have demonstrated that renin does not cross the sheep placenta and that fetal PRA is independent of the maternal PRA level.
G K Oakes; A R Fleischman; K J Catt; R A Chez
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  31     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1977  
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  208-12     Citation Subset:  IM    
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MeSH Terms
Fetal Blood / analysis
Furosemide / administration & dosage,  diagnostic use
Injections, Intravenous
Kidney / secretion*
Maternal-Fetal Exchange*
Renin / blood*,  secretion
Reg. No./Substance:
54-31-9/Furosemide; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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