Document Detail

Plasma renin activity in patients after a subarachnoid hemorrhage--a possible predictor of outcome.
MedLine Citation:
PMID:  7010196     Owner:  NLM     Status:  MEDLINE    
Plasma renin activity (PRA) was estimated in 23 patients during the 1st week after a subarachnoid hemorrhage (SAH) and in a control group of 6 postlaminectomy patients. Patients with altered levels of consciousness and neurological deficits had significantly higher levels of PRA than did patients who were alert and neurologically intact. The SAH patients were divided into three groups: (a) low renin (13 patients with a PRA of less than 1.77 pmol/ml/hour), (b) normal renin (2 patients with normal renin levels), and (c) high renin (8 patients with a PRA of greater than 2.5 pmol/ml/hour). Patients with high renin levels had a significantly higher incidence of morbidity and mortality than did those with low renin levels. There were also higher levels of urinary catecholamines in the high renin group of patients. The combination of altered consciousness, high levels of urinary catecholamines, particularly adrenaline; and a high PRA in the 1st week after a SAH indicates a poor prognosis.
G Neil-Dwyer; P Walter; H J Shaw; R Doshi; M Hodge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  7     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  578-82     Citation Subset:  IM    
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MeSH Terms
Circle of Willis
Intracranial Aneurysm / complications,  surgery
Middle Aged
Renin / blood*
Subarachnoid Hemorrhage / blood*,  surgery
Reg. No./Substance:

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