Document Detail

Plasma proteins glycosylation and its alteration in disease.
MedLine Citation:
PMID:  9562647     Owner:  NLM     Status:  MEDLINE    
Most plasma proteins are glycoproteins, that is, they possess oligosaccharide chains attached to the polypeptide core. These oligosaccharides have important structural and functional roles; they serve as recognition markers (ligands), especially for lectin receptors, thus modulating the glycoprotein interactions. Protein glycosylation is a posttranslational event which depends on the proteic core and biosynthetic cell type and results in a set of microheterogeneous forms (glycoforms) of an individual glycoprotein. Under pathological conditions an alteration of the glycosylation pattern of plasma glycoproteins occurs. So, degalactosylated IgG and IgA1 detected in rheumatoid arthritis and IgA nephropathy, respectively, are implicated in the pathogenic mechanisms. Alteration of transferrin, alpha 1-acid glycoprotein and alpha-fetoprotein glycosylation (reduced sialylation and increased branching of oligosaccharide chains) occurs in liver diseases. In inflammations and infections the alteration is dependent on the disease studied, while increased sialylation and fucosylation of acute-phase proteins are detected in cancer sera. Lectin-based methods have been developed for clinical purposes, in order to improve the diagnosis, prognosis evaluation, or treatment monitoring.
L Matei
Related Documents :
18373267 - Monitoring glycosylation of therapeutic glycoproteins for consistency by hplc using hig...
20217867 - Concanavalin a-immobilized magnetic nanoparticles for selective enrichment of glycoprot...
12485617 - Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulati...
12781527 - Campylobacter--a tale of two protein glycosylation systems.
3333727 - Purification of streptococcal protein g expressed by escherichia coli by high performan...
16216237 - Xenopus xpat protein is a major component of germ plasm and may function in its organis...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  35     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:    1997 Jan-Dec
Date Detail:
Created Date:  1998-06-02     Completed Date:  1998-06-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  3-11     Citation Subset:  IM    
Institute of Biochemistry, Bucharest, Romania.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute-Phase Proteins / metabolism
Aging / blood
Arthritis, Rheumatoid / blood
Blood Proteins / metabolism*
Glomerulonephritis, IGA / blood
Glycoproteins / blood
Immunoglobulins / blood
Oligosaccharides / blood
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Blood Proteins; 0/Glycoproteins; 0/Immunoglobulins; 0/Oligosaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Collaboration of national organizations and the legislative means to advance pulmonary rehabilitatio...
Next Document:  Effect of isometric effort upon mitral regurgitation severity--echo Doppler study.