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Plasma protein turnover and tissue exchange; influence of dietary protein and protein depletion.
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MedLine Citation:
PMID:  13620847     Owner:  NLM     Status:  OLDMEDLINE    
Abstract/OtherAbstract:
The rate of plasma protein turnover is more rapid in dogs receiving adequate dietary protein than when a diet devoid of protein is fed. Both albumin and combined globulins are involved in this change. The difference in turnover is reflected in a total protein half-life of 4.8 days with protein feeding versus 7.8 days without protein in the diet and in the metabolism of 1.0 and 0.65 gm. per kilogram of body weight per day on the respective diets. Additions of dietary protein from 10 to 30 per cent caused no further increase in the rate of plasma protein turnover. With protein depletion due to plasmapheresis and a very low protein diet there is evidence of reduced protein metabolism as indicated by nitrogen retention as well as a reduction in total plasma protein breakdown and interchange of isotope between plasma and tissue proteins. Following introduction of labeled plasma protein into the circulation the net amount of isotope transferred to tissues has been computed from the difference between total plasma protein breakdown and combined C(14) excretion in urine and expired air. In animals receiving adequate dietary protein, tissue transfer amounts to 70 per cent of the total lost from the plasma proteins each day while the percentage rises to 85 in depleted dogs deprived of protein. In dogs with both plasma and tissue proteins labeled it can be estimated that, under conditions of protein feeding, an amount of C(14) approximately equal to that lost from the plasma must recycle to account for the observed decrease in Apparent plasma protein turnover rate, (t(1/2) of 15 versus 5 days). Without protein in the diet the isotope contribution of the tissues to the maintenance of plasma protein levels must be as great as or greater than that transferred in the opposite direction.
Authors:
C L YUILE; F V LUCAS; J P OLSON; A B SHAPIRO
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  109     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1959 Feb 
Date Detail:
Created Date:  1959-12-01     Completed Date:  2000-07-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  173-86     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Blood Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Blood Proteins
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1959, by The Rockefeller Institute
Received Day: 29 Month: 9 Year: 1958
Print publication date: Day: 31 Month: 1 Year: 1959
Volume: 109 Issue: 2
First Page: 173 Last Page: 186
ID: 2136938
PubMed Id: 13620847

PLASMA PROTEIN TURNOVER AND TISSUE EXCHANGE : INFLUENCE OF DIETARY PROTEIN AND PROTEIN DEPLETION
C. L. Yuile
F. V. Lucas
J. P. Olson
A. B. Shapiro
From the Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, New York


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