Document Detail

Plasma protein levels in normal human fetuses: 13 to 41 weeks' gestation.
MedLine Citation:
PMID:  8218008     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To establish reference ranges for the levels of alpha-fetoprotein, albumin, prealbumin (transthyretin) alpha-1-antitrypsin, transferrin, ceruloplasmin and total protein in the plasma of normal human fetuses and newborn babies. DESIGN: Prospective study of individual normal cases to fulfil objectives. SETTING: Pathology laboratories of the University of Edinburgh and the biochemistry laboratories of the University of Keele. SUBJECTS: Twenty-two normal fetuses 13 to 22 weeks of gestation and 66 babies born between 24 and 41 weeks gestation. RESULTS: Albumin is the predominant plasma protein throughout gestation. The levels of alpha-fetoprotein and prealbumin fell significantly with increasing gestation, whereas the concentrations of the other proteins studied increased. The ratios of individual proteins to total protein demonstrated similar trends. CONCLUSIONS: This study provides developmental profiles of normal human fetal plasma proteins to serve as possible reference data for abnormal fetuses. Declining levels of prealbumin (transthyretin) were unexpected and suggest a functional role for this protein in early pregnancy.
A A Fryer; P Jones; R Strange; R Hume; J E Bell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  100     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-22     Completed Date:  1993-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  850-5     Citation Subset:  AIM; IM    
School of Postgraduate Medicine, University of Keele, Stoke on Trent, UK.
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MeSH Terms
Blood Proteins / metabolism*
Fetal Blood / chemistry*
Gestational Age
Infant, Newborn
Prospective Studies
Reference Values
Reg. No./Substance:
0/Blood Proteins

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