Document Detail

Plasma prostaglandin metabolites in human labor.
MedLine Citation:
PMID:  677189     Owner:  NLM     Status:  MEDLINE    
To elucidate the role of prostaglandins in initiating uterine contractions we studied the concentrations of 13,14-dihydro-15-keto-PGE2 (PGE2-M) and 13,14-dihydro-15-keto-PGF2alpha (PGF2alpha-M) in peripheral plasma of pregnant patients. The concentrations of PGE2-M and PGF2alpha-M in pregnant patients at term not in labor were not significantly different from those at midpregnancy. Induction of labor at term pregnancy caused a significant rise of both PGE2-M and PGF2alpha-M. During spontaneous labor there were no significant minute-to-minute fluctuations of plasma PGE2-M and PGF2alpha-M and their concentrations were not different from those at oxytocin-induced labor. Initiation of uterine contractions and abortion at midpregnancy by the intra-amniotic infusion of hypertonic saline was not associated with any change in PGE2-M concentration and a rise in PGF2alpha-M was noted in only one of five patients. The vaginal administration of PGE2 and the intra-amniotic infusion of PGF2alpha were associated in each case with a significant rise of both prostaglandin metabolites. It is concluded that the rise of prostaglandin metabolites in peripheral plasma is secondary to the initiation of uterine contractions at term pregnancy. Such a rise is not usually observed after the initiation of uterine contractions by hypertonic saline at midpregnancy.
R Lackritz; D Tulchinsky; K J Ryan; L Levine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  131     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-15     Completed Date:  1978-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  484-9     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Induced
Infusions, Parenteral
Labor, Induced
Oxytocin / therapeutic use
Pregnancy Trimester, Second
Prostaglandins / blood*,  physiology
Prostaglandins E / administration & dosage,  blood,  physiology
Prostaglandins F / administration & dosage,  blood,  physiology
Saline Solution, Hypertonic
Uterine Contraction*
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins E; 0/Prostaglandins F; 0/Saline Solution, Hypertonic; 50-56-6/Oxytocin

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