| Plasma prekallikrein levels are positively associated with circulating lipid levels and the metabolic syndrome in children. | |
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MedLine Citation:
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PMID: 20725119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma prekallikrein (PK) has been shown to be associated with cardiovascular disease (CVD) and its risk factors, but these associations have not been investigated in children. The present study examined PK activity in relation to well-established cardiovascular risk factors in a cohort of children aged 9-11 years (N=97). We found a significant and positive association between PK and fasting levels of total cholesterol (p<0.01), non-high-density lipoprotein cholesterol (p<0.01), and triglycerides (p<0.001). In addition, there was a significant association between PK activity and the metabolic syndrome, a clustering of risk factors considered to have an impact on atherosclerosis and CVD mortality. Finally, we found that children with a family history of CVD had significantly elevated PK activity. These novel findings warrant further investigations into the relationship between circulating PK levels and CVD risk factors because PK may be involved in the progression of the disease state. |
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Authors:
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James A MacKenzie; Kristen A Roosa; Brooks B Gump; Amy K Dumas; Kestutis G Bendinskas |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme Volume: 35 ISSN: 1715-5312 ISO Abbreviation: Appl Physiol Nutr Metab Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264333 Medline TA: Appl Physiol Nutr Metab Country: Canada |
Other Details:
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Languages: eng Pagination: 518-25 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, State University of New York College at Oswego, Oswego, NY 13126, USA. james.mackenzie@oswego.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Biological Markers / blood Cardiovascular Diseases / blood, etiology*, genetics Child Cholesterol / blood Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Linear Models Lipids / blood* Lipoproteins / blood Male Metabolic Syndrome X / blood*, complications New York Odds Ratio Pedigree Prekallikrein / analysis* Risk Assessment Risk Factors Triglycerides / blood Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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R15ES015619/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipids; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol; 9055-02-1/Prekallikrein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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