Document Detail

Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes.
MedLine Citation:
PMID:  17699548     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is conflicting epidemiological evidence concerning an increase in risk of non-Hodgkin's lymphoma (NHL) associated with elevated blood levels of persistent organochlorine (OC) pesticides and polychlorobiphenyls (PCBs). METHODS: We measured the concentration of 17 OC pesticides, including hexachlorobenzene (HCB), four lindane isomers (alpha-, beta-, gamma- and delta-hexachlorocyclohexane (HCH)), two chlordane species (heptachlor and oxy-chlordane), four cyclodiene insecticides (aldrin, dieldrin, endrin and mirex), six dichloro-diphenyl-trichloroethane (DDT) isomers and nine PCB congeners (PCBs 28, 52, 101, 118, 138, 153, 170, 180 and 194) in plasma samples of 377 subjects, including 174 NHL cases and 203 controls from France, Germany and Spain. The risk of NHL and its major subtypes associated with increasing blood levels of OC pesticides and PCBs was calculated using unconditional logistic regression. RESULTS: Risk of NHL, diffuse large B cell lymphoma (DLBCL) and chronic lymphatic leukaemia (CLL) did not increase with plasma levels of HCB, beta-HCH, p,p'-dichloro-diphenyl-dichloroethylene (DDE), or total and individual PCBs or their functional groups, in the overall study population. Substantial heterogeneity in DLBCL risk associated with immunotoxic PCBs (p = 0.03) existed between the Spanish subgroup (odds ratio (OR) for immunotoxic PCB plasma level above the median vs below the median was 0.7, 95% CI 0.3 to 1.6) and the French and German subgroups combined (OR 3.2, 95% CI 0.9 to 11.5). CONCLUSION: We did not find evidence of an association between NHL risk and plasma level of OC pesticides and PCBs.
P Cocco; P Brennan; A Ibba; S de Sanjosé Llongueras; M Maynadié; A Nieters; N Becker; M G Ennas; M G Tocco; P Boffetta
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-15
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  65     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  132-40     Citation Subset:  IM    
Department of Public Health, Occupational Health Section, Asse Didattico - Policlinico Universitario, SS 554, Km 4,500, 09042 Monserrato (Cagliari), Italy.
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MeSH Terms
Case-Control Studies
Environmental Pollutants / blood*
Hydrocarbons, Chlorinated / blood*
Leukemia, Lymphocytic, Chronic, B-Cell / blood
Logistic Models
Lymphoma, Large B-Cell, Diffuse / blood
Lymphoma, Non-Hodgkin / blood*,  chemically induced
Middle Aged
Odds Ratio
Pesticide Residues / blood*
Polychlorinated Biphenyls / blood*
Risk Assessment / methods
Reg. No./Substance:
0/Environmental Pollutants; 0/Hydrocarbons, Chlorinated; 0/Pesticide Residues; 0/Polychlorinated Biphenyls

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