Document Detail


Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes.
MedLine Citation:
PMID:  17699548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is conflicting epidemiological evidence concerning an increase in risk of non-Hodgkin's lymphoma (NHL) associated with elevated blood levels of persistent organochlorine (OC) pesticides and polychlorobiphenyls (PCBs). METHODS: We measured the concentration of 17 OC pesticides, including hexachlorobenzene (HCB), four lindane isomers (alpha-, beta-, gamma- and delta-hexachlorocyclohexane (HCH)), two chlordane species (heptachlor and oxy-chlordane), four cyclodiene insecticides (aldrin, dieldrin, endrin and mirex), six dichloro-diphenyl-trichloroethane (DDT) isomers and nine PCB congeners (PCBs 28, 52, 101, 118, 138, 153, 170, 180 and 194) in plasma samples of 377 subjects, including 174 NHL cases and 203 controls from France, Germany and Spain. The risk of NHL and its major subtypes associated with increasing blood levels of OC pesticides and PCBs was calculated using unconditional logistic regression. RESULTS: Risk of NHL, diffuse large B cell lymphoma (DLBCL) and chronic lymphatic leukaemia (CLL) did not increase with plasma levels of HCB, beta-HCH, p,p'-dichloro-diphenyl-dichloroethylene (DDE), or total and individual PCBs or their functional groups, in the overall study population. Substantial heterogeneity in DLBCL risk associated with immunotoxic PCBs (p = 0.03) existed between the Spanish subgroup (odds ratio (OR) for immunotoxic PCB plasma level above the median vs below the median was 0.7, 95% CI 0.3 to 1.6) and the French and German subgroups combined (OR 3.2, 95% CI 0.9 to 11.5). CONCLUSION: We did not find evidence of an association between NHL risk and plasma level of OC pesticides and PCBs.
Authors:
P Cocco; P Brennan; A Ibba; S de Sanjosé Llongueras; M Maynadié; A Nieters; N Becker; M G Ennas; M G Tocco; P Boffetta
Related Documents :
25181388 - A meta-analysis comparing the biochemistry of primary hyperparathyroidism in youths to ...
3367758 - Serum erythropoietin in cross-country skiers.
16583258 - Polychlorinated biphenyl concentrations, congener profiles, and ratios in the fat tissu...
25436638 - Genetic variants associated with serum thyroid stimulating hormone (tsh) levels in euro...
21686558 - Thrombotic thrombocytopenic purpura following zoledronic acid infusion with a fatal out...
19301038 - Response of different pth assays to therapy with sevelamer or caco3 and active vitamin ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-15
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  65     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  132-40     Citation Subset:  IM    
Affiliation:
Department of Public Health, Occupational Health Section, Asse Didattico - Policlinico Universitario, SS 554, Km 4,500, 09042 Monserrato (Cagliari), Italy. coccop@pacs.unica.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Environmental Pollutants / blood*
Female
France
Germany
Humans
Hydrocarbons, Chlorinated / blood*
Leukemia, Lymphocytic, Chronic, B-Cell / blood
Logistic Models
Lymphoma, Large B-Cell, Diffuse / blood
Lymphoma, Non-Hodgkin / blood*,  chemically induced
Male
Middle Aged
Odds Ratio
Pesticide Residues / blood*
Polychlorinated Biphenyls / blood*
Risk Assessment / methods
Spain
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Hydrocarbons, Chlorinated; 0/Pesticide Residues; 0/Polychlorinated Biphenyls

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhalable beta(1->3)glucans as a non-allergenic exposure factor in Dutch bakeries.
Next Document:  Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hy...