| Plasma platelet products and exercise-induced myocardial ischemia. | |
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MedLine Citation:
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PMID: 6854135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral plasma concentrations of PF-4 and TxB2 were measured by RIA in 26 patients who underwent exercise stress testing. In group A (n = 15; age 50 +/- 16, mean +/- S.D.) in whom blood sampling was performed by venipuncture, seven patients had a positive stress test associated with an increase in PF-4 concentrations from 3.3 +/- 1.6 ng/ml to 6.9 +/- 3.6 (mean +/- S.D.); six of them demonstrated a greater than 50% increase in PF-4; and only one of eight with a negative stress test had such an increase. In group B (n = 11; 49 +/- 10 yr), patients also underwent postexercise thallium-201 scanning and blood samples were obtained through an intravenous catheter. These patients consistently demonstrated higher PF-4 values (before exercise 7.5 +/- 3.9 ng/ml; after exercise 11.9 +/- 7.1), regardless of the results of the exercise and thallium studies. TxB2 concentrations were unchanged in both groups. To further evaluate the effect of catheter-collected samples on PF-4, five healthy males had serial concurrent blood sampling in opposite arms via both venipuncture and catheter. Although PF-4 concentrations in venipuncture samples were constant, those collected through the catheter increased as a function of time. On the basis of the findings in group A, enhanced platelet activation appears to be associated with exercise-induced ischemia. The observations in group B and the healthy controls indicated that catheter-collection of samples artifactually increased PF-4 concentrations. |
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Authors:
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H H Rotmensch; P H Vlasses; K L Carpenter; L F D'Amelio; B N Swanson; R K Ferguson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 102 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-07-29 Completed Date: 1983-07-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Coagulation Factors / analysis* Blood Platelets / metabolism* Blood Specimen Collection / methods Coronary Disease / blood*, etiology Exercise Test Humans Middle Aged Physical Exertion* Platelet Factor 4 / analysis* Thromboxane B2 / biosynthesis, blood |
| Grant Support | |
ID/Acronym/Agency:
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5T35HL07497/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 37270-94-3/Platelet Factor 4; 54397-85-2/Thromboxane B2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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