Document Detail


Plasma plasmin inhibitors in Duchenne-type progressive muscular dystrophy.
MedLine Citation:
PMID:  3160343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In our previous research, we found that the level of the plasminogen activity in the plasma from Duchenne-type patients with progressive muscular dystrophy was higher than of the normal boys, though the level of the plasmin inhibitors was lower. Therefore, in the present study, we investigated the differences in the fractions of plasmin inhibitors. The subjects were nine patients (the average age being 17.1 years) who had been diagnosed, by clinical and biochemical tests, as having PMD; serving as controls were normal boys (the average age being 15 years), the patients' mothers, and the mothers of the normal boys. The plasmin inhibitors were separated from plasma using lysine-Sepharose columns according to the method of Urita et al. The determination was performed based on the method of Aoyagi et al. and an immunoreactive assay. The results were as follows: (1) No significant differences were seen between patients with PMD and control subjects with respect to either alpha 1-antichymotrypsin, antithrombin III, and alpha 1-antitrypsin or alpha 2-macroglobulin and inter-alpha-trypsin inhibitors. These results suggested that the low level of plasmin inhibitors in patients was due to the low activity of the C1 inactivator. (2) The patients with PMD showed lower values than the normal boys in the levels of C1 inactivator in plasma; similarly, the mothers of these patients showed lower values than the normal mothers.
Authors:
I Shomura; N Nagao; Y Sawada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical medicine     Volume:  33     ISSN:  0006-2944     ISO Abbreviation:  Biochem Med     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-09     Completed Date:  1985-08-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0151424     Medline TA:  Biochem Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chromatography, Gel
Complement C1 Inactivator Proteins / analysis
Female
Fibrinolysin / antagonists & inhibitors*
Humans
Male
Muscular Dystrophies / blood*
alpha 1-Antitrypsin / analysis
alpha-2-Antiplasmin / analysis
Chemical
Reg. No./Substance:
0/Complement C1 Inactivator Proteins; 0/alpha 1-Antitrypsin; 0/alpha-2-Antiplasmin; EC 3.4.21.7/Fibrinolysin

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