Document Detail

Plasma plant sterols serve as poor markers of cholesterol absorption in man.
MedLine Citation:
PMID:  23178226     Owner:  NLM     Status:  MEDLINE    
The validation of the use of plasma plant sterols as a marker of cholesterol absorption is frail. Nevertheless, plant sterol concentrations are routinely used to describe treatment-induced changes in cholesterol absorption. Their use has also been advocated as a clinical tool to tailor cholesterol-lowering therapy. Prior to wider implementation, however, the validity of plant sterols as absorption markers needs solid evaluation. Therefore, we compared plasma plant sterol concentrations to gold-standard stable isotope-determined cholesterol absorption. Plasma campesterol/TC concentrations (camp/TC) were measured in a population of 175 mildly hypercholesterolemic individuals (age: 59.7 ± 5.6 years; BMI: 25.5 ± 2.9 kg/m(2); LDL-C: 4.01 ± 0.56 mmol/l). We compared cholesterol absorption according to the plasma dual-isotope method in subjects with the highest camp/TC concentrations (N = 41, camp/TC: 2.14 ± 0.68 μg/mg) and the lowest camp/TC concentrations (N = 39, camp/TC: 0.97 ± 0.22 μg/mg). Fractional cholesterol absorption did not differ between the groups (24 ± 12% versus 25 ± 16%, P = 0.60), nor was it associated with plasma camp/TC concentrations in the total population of 80 individuals (β = 0.13; P = 0.30, adjusted for BMI and plasma triglycerides). Our findings do not support a relation between plasma plant sterol concentrations and true cholesterol absorption and, therefore, do not favor the use of these sterols as markers of cholesterol absorption. This bears direct consequences for the interpretation of earlier studies, as well as for future studies targeting intestinal regulation of cholesterol metabolism.
Lily Jakulj; Hussein Mohammed; Theo H van Dijk; Theo Boer; Scott Turner; Albert K Groen; Maud N Vissers; Erik S G Stroes
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Publication Detail:
Type:  Journal Article     Date:  2012-11-25
Journal Detail:
Title:  Journal of lipid research     Volume:  54     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-21     Completed Date:  2013-09-30     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1144-50     Citation Subset:  IM    
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MeSH Terms
Cholesterol / analogs & derivatives,  blood*
Cross-Sectional Studies
Intestinal Absorption / physiology
Middle Aged
Phytosterols / blood*
Triglycerides / blood
Reg. No./Substance:
0/Phytosterols; 0/Triglycerides; 5L5O665639/campesterol; 97C5T2UQ7J/Cholesterol
Comment In:
J Lipid Res. 2013 Apr;54(4):873-5   [PMID:  23402986 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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